Compound calcium gluconate oral solution and preparation method thereof
A technology of calcium gluconate and oral solution, which is applied in the field of medicine, can solve problems such as inability to store for a long time, high calcium content, and easy precipitation, and achieve the effects of reducing crystallization rate, promoting dissolution, and improving stability
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[0040] The present invention also provides the preparation method of the compound calcium gluconate oral solution described in the above-mentioned technical scheme, comprises the following steps:
[0041] Part of the water is first mixed with calcium gluconate to obtain a first solution;
[0042] performing second mixing of the first solution and calcium lactate to obtain a second solution;
[0043] performing a third mixing of the second solution and lactic acid to obtain a third solution;
[0044] The third solution, mannitol, sweetener, citric acid, essence and remaining water are mixed for the fourth to obtain the compound calcium gluconate oral solution.
[0045] In the present invention, the temperature of the first mixing is preferably 60-70°C.
[0046] In the present invention, the temperature of the third mixing is preferably 40-50°C.
[0047] In the present invention, the volume ratio of the part of water to the remaining water is preferably 4:1.
[0048] In the ...
Embodiment
[0055] EXAMPLES The formulations of Examples 1 to 3 are shown in Table 1.
[0056] The formula of table 1 embodiment 1~3
[0057]
[0058] Preparation Process
[0059] Take 80vol% purified water of the prescription, heat to 60°C, add calcium gluconate and stir to dissolve;
[0060] Add calcium lactate, stir to dissolve, stop heating;
[0061] Cool, add lactic acid when the temperature reaches 40°C, and stir thoroughly for 30 minutes;
[0062] Add mannitol, sucralose, citric acid, essence, stir to dissolve, cool to room temperature, add remaining purified water;
[0063] After stirring and mixing evenly, the solution was filtered with a 0.2 μm filter membrane, and after filtration, it was potted, sterilized at 105°C for 45 minutes, and vacuum leak tested.
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