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Polygonatum sibiricum homogeneous polysaccharide as well as preparation method and application thereof

A Polygonatum chinensis and uniform technology is applied in the field of separation and purification of macromolecular polysaccharides in Chinese herbal medicine, and achieves the effects of difficult polysaccharide structure, good effect and high yield.

Active Publication Date: 2022-01-04
天问山生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most reports on Polygonatum Polysaccharides in the prior art are about its functions, and few people have studied Polygonatum Polysaccharides

Method used

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  • Polygonatum sibiricum homogeneous polysaccharide as well as preparation method and application thereof
  • Polygonatum sibiricum homogeneous polysaccharide as well as preparation method and application thereof
  • Polygonatum sibiricum homogeneous polysaccharide as well as preparation method and application thereof

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Embodiment 1

[0030] Embodiment 1: the preparation method of Polygonatum homogeneous polysaccharide

[0031] (1) Extraction of Polygonatum polysaccharide

[0032] Adopt distilled water leaching, ethanol precipitation method to extract Polygonatum Polysaccharides, the specific steps are: take 2.6kg of dried rhizomes of Polygonatum medicinal material that has been processed, add 500g of medicinal materials each time, add distilled water according to the ratio of solid-liquid ratio of Polygonatum to distilled water 1g: 3mL, and Decoct for 90 minutes in a slightly boiling state, filter out the medicinal liquid, repeat the extraction of the medicinal residue twice according to the above extraction method, combine the medicinal liquid and concentrate it to obtain the extract; according to the volume ratio of the extract to a 95% ethanol solution Slowly add 95% ethanol solution to the extract solution at a ratio of 1:4 while stirring. After completion, let it stand overnight, repeat the precipitat...

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Abstract

The invention discloses polygonatum sibiricum homogeneous polysaccharide and a preparation method and application thereof, and belongs to the technical field of Chinese herbal medicine macromolecular polysaccharide separating and purification. Based on the problems of separating and purification of the polygonatum sibiricum polysaccharide, composition of the polygonatum sibiricum polysaccharide, preliminary structural characterization and pharmacological action of the polygonatum sibiricum polysaccharide, in order to further research the polygonatum sibiricum polysaccharide, a water extraction and alcohol precipitation method is adopted to extract polygonatum sibiricum rhizome to obtain crude polygonatum sibiricum polysaccharide; and further the polygonatum sibiricum crude polysaccharide is purified by using an anion-cation tandem exchange resin column and a Sephacyrl S400 gel column, so that the efficiency of separating and purifying the polygonatum sibiricum homogeneous polysaccharide is improved, and the polygonatum sibiricum homogeneous polysaccharide is obtained. The rhizoma polygonati homogeneous polysaccharide does not contain impurities such as protein, nucleic acid and polypeptide, is uniform in component and relatively high in purity, has a good effect on treatment of nephritis, can be used for preparing a medicine for treating nephritis, and provides another feasible method for treatment of nephritis.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of macromolecular polysaccharides of Chinese herbal medicines, and in particular relates to a Polygonatum homogeneous polysaccharide and its preparation method and application. Background technique [0002] Polygonatum Polygonatum is the dried rhizome of Polygonatum Polygonatum, Polygonatum Polyflora and Polygonatum multiflora. As one of the traditional Chinese medicinal materials, it is also a well-known homologous medicinal material for food and medicine. It has the functions of nourishing qi and blood and strengthening the kidneys, and has high medicinal and commercial value. Polysaccharides are the components with the highest content in Polygonatum genus. Polygonatum polysaccharides have the functions of anti-aging, anti-tumor, enhancing immunity, and lowering blood fat and blood sugar. However, most of the reports on Polygonatum polysaccharide in the prior art are about i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P13/12A61P29/00
CPCC08B37/0003C08B37/0087A61K31/715A61P13/12A61P29/00Y02A50/30
Inventor 杨波张洪财郑时嘉王志刚周忠光
Owner 天问山生物科技股份有限公司
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