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Preparation method and preparation device of administrable ganglioside supplementing peptide

A technology for preparing gangliosides and preparation devices, which is applied in the field of preparation methods and preparation devices for taking ganglioside supplementary peptides, which can solve the problems of contact with outside air, peptides being oxidized, polypeptide instability, etc., to achieve inhibition Damage, induction of differentiation, good curative effect

Pending Publication Date: 2022-01-11
贵州贝斯生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, bovine brain peptide is rich in gangliosides. Gangliosides are the most important glycosphingolipids. They are abundant in the nervous system, especially in the nerve endings. There are many types. They play an important role in the transmission of nerve impulses. It has a major role in promoting regeneration and is an essential substance for the growth and development of brain nerves. Most of the nutritional peptides produced are in liquid and powder forms. Liquid peptides are easy for the human body to absorb, but the peptides in the solution are far from stable. Peptides are easily degraded by bacteria. Powdered peptides are convenient for storage and transportation, but they are also easily oxidized in the air. During storage, nitrogen or argon gas needs to be filled to reduce oxidation. However, peptide powders need to be subpackaged after production. During operation, it will be in contact with the outside air, which will cause some peptides to be oxidized and affect their quality. Therefore, we propose a preparation method and preparation device for taking ganglioside supplement peptides

Method used

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  • Preparation method and preparation device of administrable ganglioside supplementing peptide
  • Preparation method and preparation device of administrable ganglioside supplementing peptide
  • Preparation method and preparation device of administrable ganglioside supplementing peptide

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preparation example Construction

[0039] A preparation method of taking ganglioside supplementary peptides in this scheme, such as figure 1 shown, including the following steps:

[0040] (1) Mass percentage of raw and auxiliary materials: whey protein concentrate 23-25%, polydextrose 21-23%, fructo-oligosaccharide 0.9-1.1%, bovine brain peptide 1-1.1%, γ-aminobutyric acid 1-1.1% , Phosphatidylserine 0.8-0.9%, Isomaltooligosaccharide 50-55%;

[0041] (2) Pass each raw and auxiliary material through a 80-100 mesh sieve, control the moisture of each raw and auxiliary material to be ≤6.0%, and then weigh the raw and auxiliary materials according to the mass ratio of each component in the above step (1);

[0042] (3) Mix concentrated whey protein and polydextrose together, after stirring evenly, obtain mixture 1;

[0043] (4) Stir and mix the fructooligosaccharide, bovine brain peptide, and γ-aminobutyric acid at 28-32°C to obtain the mixture 2;

[0044] (5) Add mixture 1, mixture 2, phosphatidylserine, and isom...

Embodiment 1

[0057] see Figure 2-Figure 3 , a preparation device for taking ganglioside supplement peptides in the figure, including a dispensing cylinder 1, a top end of the dispensing cylinder 1 is covered with a sealing cap 2, and two sealing side doors 3 are installed on the outside of the dispensing cylinder 1, It also includes a funnel 4 and a gas isolation assembly 8 fixed in the dispensing cylinder 1. A feed pipe 5 is fixed inside the funnel 4, and the bottom end of the feed pipe 5 is fixedly connected with a plurality of shunt pipes 6. The bottom of the dispensing cylinder 1 corresponds to A dispensing assembly 7 is placed at the positions of the plurality of shunt pipes 6 , and a gas isolation assembly 8 for preventing outside air from entering when pouring the peptide powder is installed in the dispensing cylinder 1 .

[0058] It should be noted that: in this scheme, the sub-packaging cylinder 1 is a convex cylinder, and the sealing cover 2 is fastened to the outer end of the s...

Embodiment 2

[0067] see Figure 6-Figure 8 , this embodiment is further described for Example 1. The driving mechanism 14 in the illustration includes a driving shaft 20 and a driving shaft 21, and the driving shaft 20 and the driving shaft 21 are installed on the inner sides of the two ends of the U-shaped pipe 9 through brackets, and the driving The outer ends of the shaft 20 and the drive shaft 21 are all fixed with the bevel gear 15, and the installation shell 22 is fixed at the position corresponding to the drive shaft 20 of the sub-packaging cylinder 1, and the drive member 23 is installed in the installation shell 22, and the installation shell 22 is fixed with a U The air pipe 24 connected to the type pipe 9, and the air pipe 24 is located in the installation shell 22 and a solenoid valve is installed, and a conversion assembly 25 is fixed between the drive shaft 20 and the driving shaft 21.

[0068] Among them, see Figure 8 , the conversion assembly 25 in the figure includes a p...

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Abstract

The invention relates to the field of peptide manufacturing, in particular to a preparation method and a preparation device of an administrable ganglioside supplementing peptide, and the method comprises the following steps: screening concentrated whey protein, polydextrose, fructo-oligosaccharide, bovine brain peptide, [gamma]-aminobutyric acid, phosphatidylserine and isomaltooligosacharide, controlling moisture, and then quantitatively weighing; uniformly stirring concentrated whey protein and polydextrose to obtain a mixture 1; uniformly stirring and mixing fructo-oligosaccharide, bovine brain peptide and [gamma]-aminobutyric acid to obtain a mixture 2; performing high-speed mixing treatment on the mixture 1, the mixture 2, phosphatidylserine and isomaltooligosacharide to obtain a mixture; and performing vacuum drying and sterilization on the mixture. The device comprises a subpackaging cylinder, a sealing cover covers the top end of the subpackaging cylinder, the device further comprises a funnel and a gas isolation assembly, and subpackaging assemblies are placed at the positions, corresponding to a plurality of flow dividing pipes, of the bottom of the subpackaging cylinder; and the product prepared by the invention is wide in applicability and good in curative effect, and can be prevented from being in contact with external gas during subpackaging.

Description

technical field [0001] The invention relates to the technical field of peptide production, in particular to a preparation method and a preparation device of an ingestible ganglioside supplement peptide. Background technique [0002] The amino group of one amino acid and the carboxyl group of another amino acid can be condensed into a peptide. The amide group formed is called a peptide bond in protein chemistry. The molecule of an amino acid is the smallest and the protein is the largest. Two or more amino acids are dehydrated and condensed to form several peptide bonds. A peptide chain is formed, and multiple peptide chains are folded in multiple stages to form a protein molecule. Hundreds of peptides have been found in organisms, and they are essential participants for the body to complete various complex physiological activities. It involves hormones, nerves, In the fields of cell growth and reproduction, its importance lies in the regulation of various system organs and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/14A61P25/00B65B31/02B65B1/06A61K31/716A61K31/702A61K38/02A61K31/197A61K31/685
CPCA61K38/1709A61K31/716A61K31/702A61K38/02A61K31/197A61K31/685A61K9/14A61P25/00B65B31/02B65B1/06A61K2300/00
Inventor 郑颖吴贵荣钟宇明
Owner 贵州贝斯生物科技有限公司
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