Medicine component containing tobramycin inhalation solution and application thereof
A technology of tobramycin and solution, which is applied in the field of medicine, can solve the problems of large volume of residual liquid medicine, inconvenience of large volume, prolonged treatment time, etc., and achieve good effects of bronchodilation, easy to carry, and convenient to use
Active Publication Date: 2022-01-21
JIANKANGYUAN PHARMA GROUP +1
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Problems solved by technology
When the nebulizer is used for drug administration, the droplet size distribution is wide, the geometric standard deviation range is large, the volume is large, it is inconvenient to carry, the noise is large, the energy consumption is high, the residual liquid volume is large, and the treatment time is prolonged. , compliance reduction and other defects
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0057] Vibrating mesh nebulizers with different numbers of perforations but with the same other parameters were selected to test their effect on the nebulization effect when applied to tobramycin inhalation solution (prescription 1). The results are shown in Table 1.
[0058]
Embodiment 2
[0060] Vibrating mesh nebulizers with different pore diameters but with the same other parameters were selected to test their effect on the nebulization effect of tobramycin inhalation solution (prescription 1). The results are shown in Table 2.
[0061]
Embodiment 3
[0063] Vibrating mesh nebulizers with different vibration frequencies but with the same other parameters were selected to test their effect on the nebulization effect of tobramycin inhalation solution (prescription 2). The results are shown in Table 3.
[0064]
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Abstract
The present invention provides a medicine component containing a tobramycin inhalation solution and an application thereof. The medicine component comprises: (a) the tobramycin inhalation solution; and (b) the vibrating screen atomizer used in cooperation with the tobramycin inhalation solution. The central area of a metal mesh of the vibrating screen atomizer has 1400-1800 micropores. The fogdrop particle size of the tobramycin inhalation solution is as follows: D10 ranges from 0.5 [mu]m to 2.5 [mu]m, D50 ranges from 2.0 [mu]m to 4.2 [mu]m, and D90 ranges from 6.0 [mu]m to 9.0 [mu]m. The mass percentage of the particles with the aerodynamic particle size smaller than 5.39 [mu]m in the tobramycin inhalation solution is not smaller than 45%. The medicine component has a remarkable effect on clinically treating bronchiectasia.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical assembly containing tobramycin inhalation solution and its application. Background technique [0002] Aminoglycoside antibiotics are named because their molecular structure has an aminocycloalcohol and one or more aminosugar molecules, which are connected by glycosidic bonds to form glycosides. Most of them are polar compounds, which are not easily absorbed by the gastrointestinal tract. Administration by injection. Adverse events such as ototoxicity and nephrotoxicity usually occur clinically due to injection administration. Ototoxicity can be divided into: ① vestibular dysfunction, more common in streptomycin, kanamycin, gentamicin, tobramycin, the incidence rate after medication is kanamycin > streptomycin > gentamicin Tobramycin > tobramycin; ② cochlear nerve damage, which is more common in kanamycin, amikacin, sisomicin, gentamicin, etc., and the...
Claims
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IPC IPC(8): A61K9/72A61K31/702A61P11/08A61M11/00
CPCA61K9/12A61K9/0078A61K31/702A61K47/02A61P11/08A61M11/001A61M11/005
Inventor 金方黄娟邓炜杨霞郦旻俞雄
Owner JIANKANGYUAN PHARMA GROUP
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