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Hydrogel for being injected into organism and application thereof

A hydrogel and biological technology, applied in the medical field, can solve the problems of long time required, easy delay of operation or experiment time, etc., and achieve the effect of good retention, easy injection and implantation of biological body, and suitable mechanical strength

Active Publication Date: 2022-02-08
DEKE MEDTECH HANGZHOU INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current hydrogels require a long time to be prepared on site, and it is easy to delay the operation or experiment time.

Method used

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  • Hydrogel for being injected into organism and application thereof
  • Hydrogel for being injected into organism and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Set the preparation temperature to 0-25 degrees Celsius

[0079] In step (1), it is determined that the alginate component is an aqueous solution of sodium alginate and mannitol, the alkaline earth metal salt component is calcium citrate, and the aqueous solution component is water and mannitol.

[0080] Step (2), preparation of the sodium alginate component: 2 g of mannitol and 3 g of sodium alginate were dissolved in 100 g of water, and stirred until completely dissolved.

[0081] Step (3), preparation of aqueous solution components: 3.8g of mannitol was dissolved in 100g of water.

[0082] Step (4), sample loading: take a first syringe with a maximum scale of 3 ml, and connect the first syringe to a three-way valve. Remove the plunger of the first syringe and close the three-way valve. 0.021 gram of calcium citrate is packed into the first syringe, the three-way valve is opened to connect the air and the piston is put back into the first syringe, only the calcium c...

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Abstract

The invention relates to hydrogel for being injected into an organism and application thereof. The hydrogel is formed by mixing and crosslinking alkaline earth metal salt, an aqueous solution containing auxiliary materials and an alginate aqueous solution in a constant-temperature environment, and the energy storage modulus of the hydrogel is 60%-85% of the final energy storage modulus of the hydrogel; and the alkaline earth metal salt is alkaline earth metal salt containing magnesium, calcium, strontium and barium, and the form of the alkaline earth metal salt is at least one of sulfate, citrate, gluconate, lactate, carbonate, phosphate and alginate. The hydrogel disclosed by the invention is good in injecting property, can smoothly pass through a relatively long catheter, is not easy to block a needle head, also has proper mechanical strength, can resist in-situ pressure in tissues, and ensures that the hydrogel stays at a position needing to be filled after injection.

Description

[0001] This application is a divisional application for an invention titled "a hydrogel, a preparation method of a hydrogel and its application". The filing date of the original application is November 24, 2017, and the application number of the original application is 201711195532.5. technical field [0002] The present invention relates to the field of medical treatment, in particular to a hydrogel suitable for biological implantation, a preparation method of the hydrogel and an application thereof. Background technique [0003] Hydrogel is a cross-linked system fully diluted with water. It has a three-dimensional network cross-linked polymer structure, which contains a large number of hydrophilic groups, which can fill it with water, making the overall mechanical properties of the hydrogel comparable to Soft tissue is similar. Therefore, the hydrogel has both the properties of solid and liquid, and has the characteristic of changing its shape in response to the external e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/04C08K5/098A61L27/20A61L27/52A61L27/04
CPCC08J3/075C08K5/098A61L27/52A61L27/20A61L27/047A61L2400/06C08J2305/04C08L5/04
Inventor 郑吉邵南张里斯
Owner DEKE MEDTECH HANGZHOU INC
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