Stirring device with a shaft, adapted to be mounted in a fluid-mixing bioreactor, and method for assembling a stirring device.
The technology of a stirring device and a mixer is applied in the direction of a mixer with a rotating stirring device, a mixing method, biochemical equipment and methods, etc., and can solve problems such as not easy to obtain, difficult to produce rods, not suitable for one-time application, etc.
Pending Publication Date: 2022-02-18
SARTORIUS STEDIM FMT SAS
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Problems solved by technology
This solution makes the rod more difficult to produce, which is not suitable for single-use applications
In addition, this arrangement is not readily available due to inherent geometrical tolerances and possible temperature variations (expansion of the plastic part forming the rod with a non-circular cross-section may occur, causing problems for assembly operations)
Method used
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[0119] refer to figure 1 with Figure 13 to Figure 14 , providing a stirring device 1 suitable for installation in a fluid mixing system 50 which receives a biopharmaceutical fluid C for mixing, and / or for chemical and / or biological responses (or biological responses). The fluid mixing system 50 may be arranged inside the rigid outer containment device 18 and the rotatable drive shaft 2 of the stirring device has an end 25 coupled in rotation to the motorized drive part M. The fluid mixing system 50, the rigid outer containment 18, is part of the mixer vessel BR of the bioreactor.
[0120] Biopharmaceutical fluid C comprises one liquid phase or at least one liquid phase. Where appropriate, the biopharmaceutical fluid C is formed from a plurality of components, at least one of which is in a liquid phase and one or more of which may be in a solid phase, such as a powder.
[0121] The stirring device 1 here has a rotatable drive shaft 2 extending along a longitudinal axis X b...
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Abstract
A stirring device (1), in particular for a fluid-mixing bio reactor, comprises a drive shaft (2) including a rod (20), an agitating element and a sleeve (3) of tubular shape. The sleeve forms a coupling sleeve receiving the shaft (2) therethrough and is directly rotationally coupled to the rod (20). The agitating element, which has a hub (10) with an annular side wall (8) delimiting an inner space and an impeller assembly comprising blades (6b), is indirectly rotationally coupled to the rod (20) via the sleeve (3) that is engaged in the inner space. One of an inner surface (S8) of the wall (8) and an outer surface (S3) of the sleeve is a guiding surface with progressively reduced cross section. Axial movement between the hub (10) and the sleeve (3) is prevented in a locked configuration of a sleeve fastening arrangement (30, 30'). Hub-sleeve contact areas can be axially distributed.
Description
technical field [0001] The present invention relates to the field of mixer containers, more particularly to a mixer container [0002] A stirring device for a container, especially a stirring device suitable for one-time use. [0003] The invention also relates to an assembled stirring device (in particular intended for receiving biological [0004] A stirring device used in a bioreactor for mixing medicinal fluids), and a method involving [0005] And fluid mixing systems usually provided with disposable containers and stirring devices. [0006] The term "biopharmaceutical fluid" is understood to mean biotechnological products (culture media, cell cultures, buffer solutions, artificial nutrients, blood products and blood product derivatives) [0007] or pharmaceutical products or more generally products intended for use in the medical field. The present invention is also suitable for [0008] For other products with similar packaging requirements. Background technique ...
Claims
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IPC IPC(8): B01F23/231B01F27/07B01F27/113B01F27/191B01F27/192B01F35/41B01F35/513
CPCB01F23/2312B01F23/231266B01F27/071B01F27/1111B01F27/113B01F27/192B01F27/191B01F35/4121B01F35/513B01F2101/22C12M23/14C12M27/02
Inventor 叶列米·吉贝林丹尼尔·佩塞塞巴斯蒂安·普尔曼
Owner SARTORIUS STEDIM FMT SAS