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Application of tremella polysaccharide in preparation of preparation with effect of preventing and treating non-alcoholic fatty liver disease

A tremella polysaccharide, non-alcoholic technology, applied in the field of Tremella polysaccharide, can solve the problems of unclear mechanism of action, unclear active ingredients, uncontrollable quality, etc., achieve clear structural characteristics, reduce the level of non-alcoholic fatty liver, and the mechanism of action clear effect

Pending Publication Date: 2022-02-22
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polysaccharide-based traditional Chinese medicine prescriptions have problems such as unclear active ingredients, uncontrollable quality, difficulty in ensuring efficacy, and unclear mechanism of action, which limits their application.
[0005] Existing studies have shown that the main mechanism of action of polysaccharides with different structures in the treatment of NAFLD is different, and the effects vary greatly

Method used

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  • Application of tremella polysaccharide in preparation of preparation with effect of preventing and treating non-alcoholic fatty liver disease
  • Application of tremella polysaccharide in preparation of preparation with effect of preventing and treating non-alcoholic fatty liver disease
  • Application of tremella polysaccharide in preparation of preparation with effect of preventing and treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 100g of tremella polysaccharide powder, add 100L of purified water and 10g of mogroside, stir to dissolve, homogenize and sterilize to make tremella polysaccharide drink.

Embodiment 2

[0032] Take 100g tremella polysaccharide powder and crush it through a 100-mesh sieve, add 200g maltodextrin and 0.1g sucralose, mix well, add 30mL of 50% ethanol aqueous solution, stir evenly, granulate, dry in an oven at 60°C, and then A 30-mesh sieve was granulated to obtain tremella polysaccharide powder.

Embodiment 3

[0034] Take tremella polysaccharide powder 1000g and grind it through a 100-mesh sieve, add 500g of maltodextrin, 500g of lactose, and 100g of modified starch, put it into a high-speed granulator and mix evenly, then add 300mL of 50% ethanol, and after shearing and granulating, ℃ drying to moisture content <7.0wt%, granulation with a 20-mesh sieve, and then adding 0.1wt% magnesium stearate, mixing and tableting to obtain tremella polysaccharide tablets.

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Abstract

The invention provides application of tremella polysaccharide in preparation of a preparation with an effect of preventing and treating non-alcoholic fatty liver disease, wherein the tremella polysaccharide is derived from common food, is clear in structural characteristic and controllable in quality, and can effectively prevent and treat the non-alcoholic fatty liver disease. According to the invention, the tremella polysaccharide has the average molecular weight of 3*10<6> Da to 4*10<6> Da, the total sugar content of 85-90 wt% and the uronic acid content of 15-20 wt%, and does not contain protein and triple helix conformation.

Description

technical field [0001] The invention belongs to the field of medical care, and in particular relates to a tremella polysaccharide capable of preventing and treating non-alcoholic fatty liver and its application. Background technique [0002] The pathology of nonalcoholic fatty liver disease (NAFLD) mainly manifests as excessive fat accumulation in the liver, which in turn causes fatty degeneration of hepatic parenchyma. If not well controlled, there is a high probability that the disease may develop into steatohepatitis, liver fibrosis, liver cirrhosis or even liver failure or liver cancer as the disease progresses. [0003] According to statistics, the incidence of NAFLD in my country is increasing year by year. At present, there are about 150 million NAFLD patients, which have surpassed viral liver diseases and become the liver disease with the highest incidence. At present, the mechanism of NAFLD is not completely clear. Abnormal lipid metabolism, lipid peroxidation, ins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A23L33/125A23L2/38A23G3/42A23G3/36A61P1/16
CPCA61K31/715A61P1/16A23L33/125A23L2/38A23G3/42A23G3/364A23V2002/00A23V2200/30A23V2250/254A23V2250/264A23V2250/5114A23V2250/5118A23V2250/612A23V2250/5432A23V2250/606A23V2250/61A23V2250/032
Inventor 徐晓飞罗东辉管晶晶陈金华洋林
Owner GUANGDONG OCEAN UNIVERSITY
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