Blood clotting time calculation method and blood clotting analyzer

Abstract

The embodiment of the invention discloses a blood clotting time calculation method and a blood clotting analyzer, and the method comprises the steps: obtaining characteristic parameters of a blood sample, the characteristic parameters being used for evaluating the accuracy of the clotting time obtained by processing a clotting curve of the blood sample according to a derivative detection method; when the characteristic parameters meet a first characteristic condition, processing the clotting curve according to a derivative detection method to obtain the clotting time; when the characteristic parameters meet a second characteristic condition, processing the clotting curve according to a derivative detection method and a threshold value detection method, and carrying out weighting operation on processing results to obtain the clotting time; and when the characteristic parameter meets a third characteristic condition, processing the clotting curve according to a threshold detection method to obtain the clotting time. Therefore, due to the fact that the characteristic parameters can evaluate the accuracy degree of the coagulation time obtained by processing the coagulation curve of the blood sample according to the derivative detection method, different methods for processing the coagulation curve of the blood sample are selected according to the size of the characteristic parameters, and the accuracy degree of the obtained blood clotting time is effectively improved.

Description

technical field [0001] The invention relates to the technical field of blood detection, in particular to a blood coagulation time calculation method and a coagulation analyzer. Background technique [0002] Optical coagulation method is a common method to detect blood coagulation items, and it is mainly divided into transmission turbidimetry and scattering turbidimetry according to different optical measurement principles. The basic principle of the optical method is: add the measurement reagent to the sample plasma and irradiate it with analytical light, and form a coagulation curve according to the change of luminous flux or absorbance reflected in the coagulation process, so as to determine the detection coagulation end point and calculate the coagulation time. [0003] According to the cascade effect theory of blood coagulation, within a period of time after adding the reagent, due to the cascade reaction of coagulation factors, the luminous flux does not change much at ...

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Problems solved by technology

However, refer to image 3 , image 3 It is a schematic diagram of the luminous flux curve and the first-order derivative curve of the strong chyle sample; when the dH of the coagulation curve (dH is the total change of the coagulation curve as a whole, that is, the difference of the luminous flux between the "baseline period" and the "plateau period" of the curve, see figure 1 ) is too small (common in strong chyle samples or low fibrinogen samples, etc.), the first-order or second-order iso-differential curves often appear as noise-like curves (because dH is actually a first-order differential curve in the interval from the start point to the end point of the coagulation reaction If dH is too small, that is, the integral of the first-order differential curve is too small, it will generally show that the ordinate of the differential curve is too small, and the difference between the curve data in adjacent time is very small), at this time, it is often impossible to find the main peak of the differential curve, and the calculation is The accuracy of the setting time cannot be guaranteed

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