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Application of hypericum japonicum extract in preparation of anti-influenza B virus medicine
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A type of influenza B virus, Tian Jihuang technology, applied in the direction of antiviral agents, pharmaceutical formulations, plant raw materials, etc., to achieve strong effect, inhibition of influenza B virus, strong influenza B virus effect
Inactive Publication Date: 2022-03-01
SUN YAT SEN UNIV +1
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At present, although the invention patent CN202011106518.5 and the literature disclose the effect of Tianjihuang extract on the anti-new coronavirus and duck hepatitis
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Embodiment 1
[0012] Embodiment 1: the preparation of Tianjihuang aqueous extract
[0013] Take 500g of Tianjihuang dried medicinal material, add 8 times, 10 times, 12 times of water, decoct and extract at 60°C, 80°C, 100°C for 0.5h, 1.0h, 1.5h, extract 3 times, combine and filter to get Tianji Yellow water extract. The preferred conditions for the preparation process are: the extraction temperature is 100°C, the amount of water added is 12 times the amount of water, and the extraction time is 0.5 h. The obtained water extract is concentrated and dried to obtain the Tianjihuang water extract.
Embodiment 2
[0014] Example 2: Preparation of effective parts of Tianjihuang
[0015] Take 500 g of dried medicinal material Tianjihuang, add 12 times the amount of water, decoct and extract at 100°C for 0.5 h, extract three times in total, and combine the filtrates to obtain Tianjihuang water extract. After the D101 macroporous resin is adsorbed on the water extract, it is eluted with 8-12 times column volume of water and 20% ethanol, and then 3-7 times column volume of 60% ethanol is added for elution, and the 60% alcohol wash is collected. Deliquoring, concentrating, and freeze-drying to obtain the effective fraction of Tianjihuang.
Embodiment 3
[0016] Example 3: Analysis of the chemical components of the effective parts of Tianjihuang
[0017] Get 240 mg of Tianjihuang extract extract prepared in Example 2, dissolve it in 5% methanol, and analyze its chemical composition by liquid chromatography-mass spectrometry (LC-MS), and the liquid chromatography condition is two tubes Array detector; chromatographic column is packed with octadecyl bonded silica gel, 5 μm, 4.6×250mm; flow rate is about 1.0mL / min; mobile phase is a mixed solution of 0.1% acetic acid-acetonitrile (74:26).
[0018] The analysis results showed that the effective parts of Tianjihuang mainly contained dihydroquercetin-7-O-rhamnoside, dihydroquercetin, isoquercitrin, quercetin, tianjixanthin, quercetin, Its content is greater than 25%.
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Abstract
The invention discloses an application of a hypericum japonicum extract in preparation of an anti-influenza B virus drug. The herba hyperici japonici extract is prepared by adsorbing a herba hyperici japonici medicinal material water extract with macroporous resin, eluting with water, 20% ethanol and 60% ethanol in sequence, collecting 60% ethanol eluent, and concentrating, freezing and drying. The hypericum japonicum extract disclosed by the invention has a relatively strong effect of inhibiting influenza B virus, and the effect of the hypericum japonicum extract is obviously superior to that of each main monomer component and positive control medicine Lianhua antipyretic capsule and oseltamivir phosphate.
Description
technical field [0001] The present invention relates to the application of Chinese medicine extract, in particular to a kind of effective part of Tianjihuang and its medicinal use. Background technique [0002] Influenza B virus (influenza B virus) is a single-stranded negative-sense RNA virus belonging to the Orthomyxoviridae family. It causes local outbreaks or seasonal epidemics of influenza together with influenza A virus every year. The main susceptible population is adolescents aged 5-19 and the elderly. The seasonal epidemic peak period of influenza B virus lasts longer than that of influenza A virus, and the number of people infected in some epidemic seasons even exceeds that of influenza A, such as seasonal influenza in 2017-2018, and more than 60% of influenza infection cases in Europe are Influenza B viruses are responsible for one-third of the world's annual burden of influenza-related disease. Due to the high antigenic variability of influenza viruses and the ...
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Application Information
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