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Synthesis method of bromhexine hydrochloride suitable for industrialization

A technology of bromhexine hydrochloride and a synthesis method, applied in the field of industrial production, can solve problems such as waste of raw and auxiliary materials, and achieve the effects of improving production efficiency, improving collection effect, and shortening reaction time

Active Publication Date: 2022-03-18
江苏中渊化学品有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a synthetic method of bromhexine hydrochloride suitable for industrialization, which solves the problems of waste of raw and auxiliary materials, etc.

Method used

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  • Synthesis method of bromhexine hydrochloride suitable for industrialization
  • Synthesis method of bromhexine hydrochloride suitable for industrialization
  • Synthesis method of bromhexine hydrochloride suitable for industrialization

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Embodiment Construction

[0032] use Figure 1-Figure 6 A synthetic method of bromhexine hydrochloride suitable for industrialization according to an embodiment of the present invention is described as follows.

[0033] Such as Figure 1-Figure 6 Shown, a kind of synthetic method applicable to industrialized bromhexine hydrochloride of the present invention comprises the following steps;

[0034] S1: Use 3,5-dibromo-2-aminobenzaldehyde as the raw material, diisobutylaluminum hydride, aluminum hydride, sodium cyanoborohydride or 9-BNN as the reducing agent, and the solvent can be methanol, ethanol and other low-grade Fatty alcohol, preferably methanol; reduction of 3,5-dibromo-2-aminobenzaldehyde to 3,5-dibromo-2-aminobenzyl alcohol;

[0035] S2: 3,5-dibromo-2-aminophenyl alcohol is reacted at 7°C with concentrated hydrochloric acid and zinc chloride system, adding a small amount of phosphorus trichloride (0.02eq) to obtain 2,4-dibromo-6-( Chloromethyl)-aniline hydrochloride;

[0036] S3: 2,4-dibromo-...

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Abstract

The invention belongs to the field of industrial production, and particularly relates to a bromhexine hydrochloride synthesis method suitable for industrialization, a guide pipe is arranged at the top of a reaction cylinder, the top of the reaction cylinder is fixedly connected with the bottom of the guide pipe, and transmission pipes are symmetrically arranged at the two ends of the guide pipe; the bottom of the conveying pipe is fixedly connected with the top of a reaction cylinder, a heat preservation cylinder is arranged on the outer surface of the reaction cylinder, the outer surface of the reaction cylinder is fixedly connected with the two ends of the heat preservation cylinder, a low-temperature mechanism is arranged in the heat preservation cylinder, and the inner wall of the heat preservation cylinder is fixedly connected with the two ends of the low-temperature mechanism; a supporting mechanism is arranged at the bottom of the reaction cylinder, the bottom of the reaction cylinder is fixedly connected with the top of the supporting mechanism, a flow guide mechanism is arranged in the supporting mechanism, the inner wall of the supporting mechanism is in contact with the bottom of the flow guide mechanism, and supporting plates are uniformly arranged at the bottom of the flow guide mechanism; and the bottom of the flow guide mechanism is in contact with the top of the supporting plate.

Description

technical field [0001] The invention belongs to the field of industrial production, in particular to a synthetic method of bromhexine hydrochloride suitable for industrialization. Background technique [0002] Bromhexine hydrochloride, alias bromhexylamine hydrochloride, Bishouping, Bixiaophlegm, bromhexylcyclohexylamine, chemical name is N-methyl-N-cyclohexyl-2-amino-3,5-dibromobenzyl Amine hydrochloride, molecular formula: C14H20Br2N2·HCL, molecular weight: 412.60, bromhexine hydrochloride is a commonly used expectorant at home and abroad, has a strong mucus-dissolving effect, can break down polysaccharides and cellulose in sputum, and inhibit acidic mucopolysaccharides Protein synthesis, reduce sputum viscosity, facilitate coughing. It is clinically suitable for patients with chronic bronchitis, asthma, bronchiectasis, silicosis and other diseases with sticky phlegm that is difficult to cough up. Bromhexine hydrochloride has good safety in clinical application and defin...

Claims

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Application Information

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IPC IPC(8): C07C213/00C07C215/68C07C209/74C07C209/68C07C211/52B01J4/00B01J19/00
CPCC07C213/00C07C215/68C07C209/74C07C209/68C07C211/52B01J19/0013B01J4/001C07C2601/14
Inventor 朱敏亮肖元超陈小林
Owner 江苏中渊化学品有限公司
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