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Novel glycoside compound, pharmaceutical composition, preparation method and application

A technology of glycosides and compounds, applied in the field of medicine, to achieve obvious inhibitory effect

Active Publication Date: 2022-03-22
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new chemical entity called beta glucan was discovered earlier than other molecules previously known to have this property. By comparing it with certain sugars like sucrose, they were able to prevent the action of these substances from causing damage when ingested through stomach acid into pancreatic juice. These properties make betaine analogs useful drugs against diseases such as insulin resistance caused by excessive accumulation of body fat due to obesity.

Problems solved by technology

This patented problem addressed in the current study relates to studying how certain chemical components from different parts of Euphorbiae have potential effects against various diseases such as type 2 diabetic neuropathy caused by insulin resistance syndrome.

Method used

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  • Novel glycoside compound, pharmaceutical composition, preparation method and application
  • Novel glycoside compound, pharmaceutical composition, preparation method and application
  • Novel glycoside compound, pharmaceutical composition, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1. The preparation method of glycoside compound Euphorbiacetophenone E and 1,2,3-tri-O-galloyl-β-D-glucopyranose

[0056] Step S1: take the root of Euphorbia chamaejasma, dry and pulverize, add 8-15 times the amount of solvent to reflux for extraction for 1-3 hours, repeat 2-4 times, combine the extracts, filter, and concentrate under reduced pressure to obtain a concentrate; extract The temperature is 65°C-85°C;

[0057] The extraction solvent can be selected from water, methanol, ethanol or mixtures thereof, preferably 60-95% ethanol; (10 times the amount of 80% ethanol solvent is added in this embodiment, reflux extraction for 2 hours, repeated 3 times).

[0058] Step S2: Extract the concentrated solution with an organic solvent for 2-5 times, combine the organic phases, recover the organic solvent, and obtain the extract III; the extraction temperature is from 65°C to the boiling point of the extraction solvent;

[0059] The organic extraction solvent ca...

Embodiment 2

[0065] Others are the same as Example 1, the difference is:

[0066] Step S1: In this embodiment, 8 times the amount of 50% ethanol solvent was added, and the extraction was carried out under reflux for 1 hour, and repeated twice.

[0067] Step S2: In this example, the concentrated solution was extracted twice with an organic solvent, and the solvent was propyl acetate.

[0068] Step S3: In this embodiment, the eluent of silica gel column chromatography is petroleum ether-acetone, the eluent of reverse phase silica gel column chromatography is methanol-water, and the material of Sephadex Gel column chromatography is Sephadex G -10, the eluent is dichloromethane-methanol.

[0069] Step S4: In this embodiment, a C4 liquid chromatography column is selected, and acetonitrile-water is selected as the mobile phase.

Embodiment 3

[0071] Others are the same as Example 1, the difference is:

[0072] Step S1: In this example, 15 times the amount of 95% ethanol solvent was added, and the reflux extraction was performed for 3 hours, which was repeated 4 times.

[0073] Step S2: In this example, the concentrated solution was extracted 5 times with an organic solvent, and the solvent was propyl acetate.

[0074] Step S3: In this embodiment, the eluent of silica gel column chromatography is cyclohexane-ethyl acetate, the eluent of reverse phase silica gel column chromatography is methanol-water, and the material of Sephadex column chromatography It is Sephadex G-10, and the eluent is petroleum ether-chloroform-methanol.

[0075] Step S4: In this embodiment, a C6 liquid chromatography column is selected, and acetonitrile-water is selected as the mobile phase.

[0076] It should be noted that Examples 2-3 of the present invention and other preparation method examples not shown in the present invention are all ...

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Abstract

The invention provides a novel glycoside compound, a pharmaceutical composition, a preparation method and application, and relates to the technical field of medicines. The novel glycoside compound has a parent nucleus structure as shown in a formula I. According to the present invention, the glycoside compound having the mother nucleus structure is separated from Euphorbia fischerichia Steud, and the obvious inhibition effect of the compound on alpha-glucosidase is creatively found, such that the compound can be used for preparing the drugs for treating diabetes-related diseases, and has broad application prospects.

Description

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Claims

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Application Information

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Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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