Production process of N-benzyl hydroxylamine hydrochloride

Abstract

The invention relates to an organic synthesis intermediate, and particularly discloses a production process of N-benzyl hydroxylamine hydrochloride, which comprises the following steps: oxidation: dissolving dibenzylamine in a solvent, and adding an oxidizing agent for oxidation reaction under the catalysis of a metal oxide to obtain an oxide; ammonolysis: dissolving the oxide in an ether solvent, adding an ammonolysis solution, and carrying out ammonolysis to obtain N-benzyl hydroxylamine hydrochloride; the ammonolysis solution is a mixture of methanol and hydroxylamine hydrochloride. According to the preparation method of the N-benzyl hydroxylamine hydrochloride, few byproducts are obtained, the metal oxide is used as the catalyst, the catalytic effect is good, the oxidation reaction efficiency and the oxidation reaction conversion rate are improved, the oxide is dissolved in the ether solvent, the ammonolysis reaction conversion rate is improved, and the yield of the N-benzyl hydroxylamine hydrochloride is improved. Therefore, the yield of the N-benzyl hydroxylamine hydrochloride is improved.

Description

technical field [0001] The application relates to an organic synthesis intermediate, in particular to a production process of N-benzyl hydroxylamine hydrochloride. Background technique [0002] As an important intermediate in organic synthesis, N-benzylhydroxylamine hydrochloride plays an important role in nitrone chemistry. N-benzylhydroxylamine hydrochloride is condensed with aldehydes and ketones or added to C-C triple bonds to generate N-benzyl nitrone, and the resulting nitrone undergoes 1,3-cycloaddition reaction, which is a kind of isoxazole effective method of morphine. This method is often used to synthesize biologically active compounds and plays a unique role in drug synthesis. [0003] The commonly used synthesis method of N-benzylhydroxylamine hydrochloride is to directly utilize the benzylation reaction of hydroxylamine to carry out synthesis. The cost of this synthesis method is relatively low, but the main product of the reaction is N,N-dibenzylhydroxylamin...

AI Technical Summary

Problems solved by technology

[0003] The commonly used synthesis method of N-benzylhydroxylamine hydrochloride is to directly utilize the benzylation reaction of hydroxylamine to carry out synthesis. The cost of this synthesis method is relatively low, but the main product of the reaction is N,N-dibenzylhydroxylamine , resulting in a lower yield of N-benzylhydroxylamine hydrochloride

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