Formulations of PSMA imaging agents
A technology of preparation and aqueous preparation, applied in the field of preparation of compounds
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Embodiment 1
[0153] Labeling buffer (acetate, 50 μL, 1 M, pH 5.0) was added to an acid-washed 500 μL microcentrifuge tube, followed by 10 μL of the stock solution of Formula I. Add to the buffer solution [ 64 Cu]CuCl 2 0.02M HCl solution (25 μL, 116 MBq). The microcentrifuge tube was sealed and the radioactivity present in the reaction was measured using a dose calibrator. Transfer the centrifuge tube to an Eppendorf Thermomixer C and heat at 40°C for 20 minutes. At 20 minutes, the reactant was taken out from the thermomixer, and a sample (5 μL) was taken from the reactant, diluted with 1:1 ethanol:water solution (5 μL) and injected into a radioactive high-performance liquid chromatography system (QC1, 5 μL) middle. The reaction mixture was at room temperature while a final analysis was performed to determine if the radiochemical yield was >95%, which took 7 minutes.
Embodiment 2
[0155] Labeling buffer (acetate, 50 μL, 1 M, pH 5.0) was added to an acid-washed 500 μL microcentrifuge tube, followed by 5 μL of the stock solution of Formula I. Add to the buffer solution [ 64 Cu]CuCl 2 0.02M HCl solution (25 μL, 109 MBq). The microcentrifuge tube was sealed and the radioactivity present in the reaction was measured using a dose calibrator. Transfer the centrifuge tube to an Eppendorf Thermomixer C and heat at 40°C for 20 minutes. At 20 minutes, the reactant was taken out from the constant temperature mixer, and a sample (5 μL) was taken from the reactant, diluted with 1:1 ethanol:water solution (5 μL) and injected into a radioactive high performance liquid chromatography system (QC1, 5 μL )middle. The reaction mixture was at room temperature while a final analysis was performed to determine if the radiochemical yield was >95%, which took 7 minutes.
Embodiment 3
[0157] Labeling buffer (acetate, 600 μL, 1 M, pH 5.0) was added to an acid-washed 1500 μL microcentrifuge tube, followed by 20 μL of the stock solution of Formula I. Add to the buffer solution [ 64 Cu]CuCl 2 0.02M HCl solution (300 μL, 1136MBq). The microcentrifuge tube was sealed and the radioactivity present in the reaction was measured using a dose calibrator. Transfer the centrifuge tube to an Eppendorf Thermomixer C and heat at 40°C for 20 minutes. At 20 minutes, the reactant was taken out from the constant temperature mixer, and a sample (5 μL) was taken from the reactant, diluted with 1:1 ethanol:water solution (5 μL) and injected into a radioactive high performance liquid chromatography system (QC1, 5 μL )middle. The reaction mixture was at room temperature while a final analysis was performed to determine if the radiochemical yield was >95%, which took 7 minutes.
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