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Use of MDM2 inhibitors for treatment of myelofibrosis

A technology of myelofibrosis and MDM2, applied in the field of drug combination for treating MF

Pending Publication Date: 2022-05-06
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ruxolitinib has changed the treatment paradigm for patients with MF, there is no clear indication of a disease-modifying effect (Cervantes 2014), and treatment-related anemia is often an expected disadvantage (Naymagon and Mascarenhas 2017, Mead et al 2015)

Method used

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  • Use of MDM2 inhibitors for treatment of myelofibrosis
  • Use of MDM2 inhibitors for treatment of myelofibrosis
  • Use of MDM2 inhibitors for treatment of myelofibrosis

Examples

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Embodiment Construction

[0029] Certain terms used herein are described below. The compounds or biological agents of the invention are described using standard nomenclature. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0030] As used herein, the term "combination", "therapeutic combination" or "pharmaceutical combination" refers to a fixed combination in one dosage unit form, or a non-fixed combination, or a kit of parts for administration in combination , wherein two or more therapeutic agents may be administered independently at the same time or within time intervals, especially where these time intervals allow the combination partners to exhibit a cooperative (eg, synergistic) effect.

[0031] The term "combination therapy" refers to the administration of two or more therapeutic agents to treat the conditions or disorders being treated described in this di...

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Abstract

The present invention relates to the use of MDM2 inhibitors in the treatment of myelofibrosis (MF). The invention also relates to a pharmaceutical combination comprising a) an MDM2 inhibitor, and b) at least one additional therapeutic agent, preferably rusotinib or a pharmaceutically acceptable salt thereof.

Description

[0001] The present invention relates to the use of MDM2 inhibitors and combinations thereof. technical field [0002] The present invention relates to the use of MDM2 inhibitors in the treatment of myelofibrosis (MF). The present invention also relates to a pharmaceutical combination comprising a) an MDM2 inhibitor and b) at least one additional therapeutic agent for the treatment of MF. Background technique [0003] Myeloproliferative neoplasms (MPNs) are a unique and heterogeneous group of hematologic disorders characterized by the proliferation and accumulation of mature myeloid cells, including myelofibrosis (MF), essential thrombocythemia (ET), and erythrocyte vera polycythemia (PV). Importantly, MF is the most severe form of Philadelphia chromosome-negative (ie, BCR-ABL1-negative) myeloproliferative neoplasms, with a prevalence estimated at 2.2 cases per 100,000 population. Myelofibrosis (MF) can present as a de novo disorder (PMF) or evolve from prior PV or ET (PPV-...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K31/496A61P35/00
CPCA61K31/506A61K31/496A61P35/00A61K31/519A61K2300/00
Inventor A·埃利亚松N·格雷罗C·麦勒H·门森M·沃克罗夫斯卡K·G·J·瓦纳斯
Owner NOVARTIS AG
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