Application of molybdenum-based polyoxometallate cluster in treatment of inflammatory diseases

A technology of polyoxometalates and inflammatory diseases, which is applied in the field of medicine and can solve problems such as unsatisfactory control effects, bone marrow suppression, and liver and kidney function effects

Active Publication Date: 2022-05-13
THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in addition to the unsatisfactory control effect of these drugs, long-term use can cause adverse complications such as bone marrow suppression, osteoporosis, liver and kidney function are affected, etc.

Method used

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  • Application of molybdenum-based polyoxometallate cluster in treatment of inflammatory diseases
  • Application of molybdenum-based polyoxometallate cluster in treatment of inflammatory diseases
  • Application of molybdenum-based polyoxometallate cluster in treatment of inflammatory diseases

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Embodiment Construction

[0031] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0032] The molybdenum-based polyoxometallate clusters involved in the following experiments were synthesized by:

[0033] Weigh 2 mmol of ammonium molybdate tetrahydrate and dissolve in 10 mL of ultrapure water, and set aside; dissolve 1.17 mmol of sodium dihydrogen phosphate in 5mL of ultrapure water, and set aside. Prepare 2 mL L-ascorbic acid saturated solution, set aside. Add the sodium dihydrogen phosphate solution quickly to the ammonium molybdate solution and continue to stir for 15 min; add the saturated ascorbic acid solution dropwise to the above reaction system, the solution changes from transparent to blue-green, after the addition, continue to stir for 15 min; the solution changes from blue-green to blue-green Turn blue, add 180 mL of absolute ethanol for separation; after repeated separation and washing, and finally vac...

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Abstract

The invention discloses an application of a molybdenum-based polyoxometallate cluster in treatment of inflammatory diseases. The inflammatory disease is related to the rising of the ROS level. Experiments show that the molybdenum-based polyoxometallate cluster achieves the purpose of preventing or treating inflammatory diseases by reducing the ROS level in tissues. Therefore, the molybdenum-based polyoxometallate cluster can be used for preparing the medicine for treating the inflammatory diseases, the application of the molybdenum-based polyoxometallate cluster is widened, the new medicine for treating the inflammatory diseases is developed, an experimental basis is provided for treating clinical inflammatory diseases by the molybdenum-based polyoxometallate cluster, and the molybdenum-based polyoxometallate cluster has a good application prospect. The invention also provides a medicine for treating inflammatory diseases. The medicine for treating the inflammatory diseases can be used for effectively treating the inflammatory diseases.

Description

technical field [0001] The invention relates to the application of molybdenum-based polyoxometalate clusters in treating inflammatory diseases, and belongs to the technical field of medicine. Background technique [0002] Inflammation is a normal response of the body to harmful stimuli (tissue damage, pathogens, etc.), and normally removes damaged tissue and initiates tissue repair. Inflammatory diseases are diseases characterized by chronic inflammation, and this inflammation attacks and damages normal tissues, which is not conducive to the recovery of the body. Such disorders include, but are not limited to: dermatomyositis, Graves' disease, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus (SLE), sarcoidosis, Sjogren's syndrome, amyloidosis, Hashimoto's thyroid arthritis, vasculitis, rheumatoid arthritis, reactive arthritis, polymyositis, scleroderma, Addison's disease, leukoplakia, pernicious anemia, glomerulonephritis, severe celiac disease, type 1 di...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61P29/00A61P1/04
CPCA61K33/24A61P29/00A61P1/04
Inventor 李丹杨帆陈岳川单鸿
Owner THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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