Application of sipeimine in preparation of medicines for preventing and/or treating ulcerative colitis
A technology for ulcerative colitis and sibesin, which is applied in the field of medicine, can solve the problems of anti-ulcerative colitis and other problems that have not been seen in sibesin, and achieves prevention and intestinal tissue pathological damage, excellent anti-ulcerative colitis activity, The effect of improving the pathological injury of intestinal tissue
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Embodiment 1
[0048] Embodiment 1 sibecillin is to safety experiment
[0049] Eighteen healthy male C57BL / 6J mice with a body weight of about 20 g were randomly divided into 3 groups, 6 in each group, namely the control group, the Sibesil (9mg / kg) group and the Sibesil (18mg / kg) group. After adapting to the environment for one week, prepare sibesil with physiological saline, and administer according to the body weight of experimental mice every day, sibesil (9mg / kg) group is given sibesil for gavage administration 9mg / kg, sibesil ( 18mg / kg) group was given 18mg / kg of Sibesu by intragastric administration, and 100 μ L of normal saline was administered by intragastric administration to the control group for 7 days, and the death, body weight, intestinal tissue, colon and cecum pathological changes of each group of experimental mice were recorded simultaneously. Condition.
[0050] Experimental results such asfigure 1 , figure 2 , image 3 with Figure 4 shown. The results showed that th...
Embodiment 2
[0051] The influence of embodiment 2 sibesil on disease symptom of ulcerative colitis mice
[0052] 50 healthy male C57BL / 6J mice with a body weight of about 20 g were randomly divided into 5 groups, 10 in each group, i.e. the control group, model group, positive drug group, Sibesil (9mg / kg) group and Sibesil ( 18mg / kg) group. After adapting to the environment for one week, the mice were administered daily according to the body weight of the experimental mice. The control group drank normal water and administrated 100 μL of normal saline. Sibesu (18mg / kg) group was administered 18mg / kg by intragastric administration of Sibeisu, 100 μ L of normal saline was administered by intragastric administration to the model group, and 150 mg / kg of 5-aminosalicylic acid was administered by intragastric administration to the positive drug group. medicine for 7 days. After administration on the first day, 3% dextran sodium sulfate (Dextran Sulfate Sodium Salt, DSS) was added to the drinkin...
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