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Application of 5 '-methylthioadenosine in preparation of obesity inhibition drugs or health care products

A technology of methylthioadenosine and health products, which is applied in the field of medicine, can solve the problems that there are no 5′-methylthioadenosine obesity-suppressing drugs or health products, achieve good application prospects, and improve oral glucose tolerance and insulin sensitivity, better results

Pending Publication Date: 2022-05-20
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

[0007] At present, there is no relevant report on the use of 5'-methylthioadenosine in the preparation of obesity-suppressing drugs or health products

Method used

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  • Application of 5 '-methylthioadenosine in preparation of obesity inhibition drugs or health care products
  • Application of 5 '-methylthioadenosine in preparation of obesity inhibition drugs or health care products
  • Application of 5 '-methylthioadenosine in preparation of obesity inhibition drugs or health care products

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the examples. It should be noted that the following descriptions are only for explaining the present invention and not limiting its content.

[0025] Synthesis of MTA ( figure 1 ):

[0026] 5'-Methylthioadenosine (MTA) is produced by fermentation of human intestinal bacteria (Bifidobacterium longum). Bifidobacterium longum is inoculated in an anaerobic fermentation tank, and GMM medium with a certain concentration of methionine is used to culture for 24 hours. The GMM medium was lyophilized and extracted with 70% ethanol aqueous solution, the supernatant was concentrated and centrifuged at 12000r / min at a high speed, and separated and purified by a preparative liquid chromatography system to obtain 5'-methylthioadenosine with a purity >98% monomer.

[0027] Microbial synthesis pathways and isotope synthesis products see figure 1 .

[0028] 1. Comparison of MTA and adenosine

[0029] Experimen...

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Abstract

The invention discloses an application of 5 '-methylthioadenosine in preparation of obesity inhibition drugs or health care products, and animal experiments prove that 5'-methylthioadenosine has an obvious inhibition effect on obesity and has a good application prospect in preparation of the obesity inhibition drugs or health care products.

Description

technical field [0001] The invention relates to the application of 5'-methylthioadenosine in the preparation of obesity-suppressing drugs or health products, and belongs to the technical field of medicine. Background technique [0002] Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of body fat, and it is also an inducing factor for many other diseases, which will increase the incidence of type II diabetes, high blood pressure, cancer and other diseases. With rapid economic development and changes in people's lifestyles, the incidence of obesity in the global population has increased significantly, becoming an increasingly serious global health problem. According to the statistics of the World Health Organization (WHO), nearly 2.3 billion adults and children in the world are overweight (BMI≥25kg / m2) in 2019 (Sung et al. CA: a cancer journal for clinicians, 2019, 69(2): 88-112.). At present, the molecular mechanism and intervention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P3/04A23L33/10
CPCA61K31/7076A61P3/04A23L33/10A23V2002/00A23V2200/332
Inventor 曹岗吕强
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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