Ceramic calcium phosphate bone cement and preparation method thereof

Abstract

The invention provides ceramic calcium phosphate bone cement and a preparation method thereof. The preparation method of the ceramic calcium phosphate bone cement comprises the following steps: preparing beta-TCP ceramic particles; distilled water is selected as a liquid phase of the ceramic calcium phosphate bone cement; and carrying out self-curing reaction on the beta-TCP ceramic particles and monocalcium phosphate powder in the liquid phase to obtain the ceramized calcium phosphate bone cement. The plastic ceramic calcium phosphate bone cement and the injection ceramic calcium phosphate bone cement are respectively formed by adopting preparation processes of a mixing method and a blending method. According to the technical scheme, the ceramic calcium phosphate bone cement is higher in chemical stability, better in operability, higher in mechanical property and more controllable in degradability; and particularly, inflammatory response and damage to tissues and organs caused by the generation of the degraded particles can be avoided or reduced after the implant is implanted into a body.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a ceramicized calcium phosphate bone cement and a preparation method thereof. Background technique [0002] The ideal bone repair material should have good biocompatibility, non-toxic and harmless to the human body, or low toxicity; the material should be easy to shape to meet the needs of different transplant sites; suitable material microstructure to ensure tissue ingrowth and nutrient supply; able to It is gradually degraded and replaced by new bone in the body. Bone cement is one of the members of bone repair biomaterials, which forms self-curing through the physicochemical and chemical reactions of solid and liquid phases. Bone cement can be delivered to the target site through a small surgical incision or even percutaneous injection, which simplifies and minimises the treatment and promotes the recovery of patients. [0003] In the 1980s, Dr. Brown and Chow researched ...

AI Technical Summary

Problems solved by technology

However, the solid phase used in the existing preparation of calcium phosphate bone cement is powder, and the calcium phosphate bone cement formed by the chemical reaction between powder and powder will degrade and produce many particles after planting into the human body, and these Particles trigger an inflammatory response that can cause damage to human tissue

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