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Composition for relieving osteoarthrosis pain as well as preparation method and application thereof

A composition and bone joint technology, applied in application, drug combination, pharmaceutical formula, etc., can solve the problems of liver and kidney metabolism burden, dependence on patient absorption capacity, limited effect, etc.

Pending Publication Date: 2022-07-08
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Western medicine usually takes calcium-containing nutrients such as calcium carbonate to supplement calcium to increase bone strength in the treatment of osteoarthritis. However, the effect of such nutrients is limited and depends on the patient's absorption capacity. burden

Method used

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  • Composition for relieving osteoarthrosis pain as well as preparation method and application thereof
  • Composition for relieving osteoarthrosis pain as well as preparation method and application thereof
  • Composition for relieving osteoarthrosis pain as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1 Preparation of traditional Chinese medicine composition tablet

[0071] The traditional Chinese medicine composition of this example is made from the following raw materials: 140g of wolfberry fruit, 140g of raspberry, 140g of Polygonatum chinensis, 140g of Chinese yam, 140g of ginseng, 140g of peach kernel, 140g of pueraria, add 20 times of water, decocted and extracted 4 times, each time 0.5 h, the extracts were combined, and the extracts were concentrated under reduced pressure at 70°C into extracts with a relative density of 1.10-1.30 (55±5°C);

[0072] The extract is dried and pulverized, an appropriate amount of auxiliary materials or additives are added, mixed, granulated, dried, mixed together, compressed into tablets, and coated to make 1000 tablets.

Embodiment 2

[0073] The preparation of embodiment 2 traditional Chinese medicine composition hard capsule

[0074] The traditional Chinese medicine composition of this embodiment is made from the following raw materials: 245g of wolfberry fruit, 210g of raspberry, 175g of Polygonatum chinensis, 140g of Chinese yam, 105g of ginseng, 70g of peach kernel, 35g of pueraria, add 15 times of water, decoct and extract 3 times, each time 1.0 h, the extracts were combined, and the extracts were concentrated under reduced pressure at 70°C into extracts with a relative density of 1.10-1.30 (55±5°C);

[0075] Dry and pulverize the extract, add appropriate amount of auxiliary materials or additives, mix, granulate, dry, mix, and fill to make 1,000 tablets.

Embodiment 3

[0076] The preparation of embodiment 3 traditional Chinese medicine composition oral liquid

[0077] The traditional Chinese medicine composition of this embodiment is made from the following raw materials: 198g of wolfberry fruit, 132g of raspberry, 198g of Polygonatum chinensis, 198g of Chinese yam, 66g of ginseng, 66g of peach kernel, 132g of pueraria, add 12 times of water, decoct and extract 3 times, each time 1.5 h, the extracts were combined, and the extracts were concentrated under reduced pressure at 70°C into extracts with a relative density of 1.10-1.30 (55±5°C);

[0078] The extract is ethanol-precipitated and centrifuged to obtain a mixed extract, water is added to the mixed extract, mixed evenly, and packaged to prepare 1,000 oral liquids.

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Abstract

The invention provides a composition for relieving osteoarthrosis pain and a preparation method and application thereof, and relates to the technical field of medicines, health care products and food. The composition has the effect of improving bone mineral density and comprises the following components in parts by weight: 1-12 parts of fructus lycii, 1-12 parts of fructus rubi, 1-15 parts of rhizoma polygonati, 1-30 parts of rhizoma dioscoreae, 1-9 parts of ginseng, 1-10 parts of peach kernel and 1-15 parts of radix puerariae. The invention further provides a preparation method of the composition, and the preparation method comprises the following steps: performing hydrated extraction, concentration, drying and crushing on the fructus lycii, the raspberry, the rhizoma polygonati, the Chinese yam, the ginseng, the peach kernel and the radix puerariae, then uniformly mixing with the collagen peptide, the hydrolyzed yolk powder, the bovine colostrum basic protein and the vitamin C, and adding auxiliary materials to prepare an oral preparation. In the application, the compatibility and dosage of the medicinal materials are researched and investigated through a medicine screening experiment, and animal experiments prove that the composition has a therapeutic effect of improving the bone mineral density.

Description

technical field [0001] The present application relates to the technical fields of medicines, health products and food, and in particular, to a composition for relieving pain in bone and joints, and a preparation method and application thereof. Background technique [0002] Osteoarthropathy is a degenerative disease caused by the gradual aging of joint tissues or the hyperplasia of cartilage. Patients will experience joint pain, stiffness, stiffness, swelling, and deformity. In severe cases, muscle atrophy may occur. It belongs to traditional Chinese medicine. "Bone Bi", "Bone Atrophy", "Bone Pain" and other categories. [0003] The main symptom of osteoarthritis is pain, which is mild and dull at first, but not serious, and gradually worsens later. The pain intensifies when the patient is active for a long time, and gets better after rest. Some patients feel pain at rest or when they get up in the morning, but relieve after a little activity, which is called "rest pain", wh...

Claims

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Application Information

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IPC IPC(8): A61K38/39A23G3/48A23L2/39A23L33/105A61P19/02A61P29/00A61K31/375
CPCA61K36/815A61K36/73A61K36/8969A61K36/8945A61K36/258A61K36/736A61K36/488A61K38/39A61K38/1709A61K38/012A61K31/375A61P19/02A61P29/00A23L33/105A23L2/39A23G3/48A23V2002/00A61K2300/00A23V2200/30A23V2250/21
Inventor 肖伟张海弢王振东李曼曼范业文马静雯胡晗绯李旭顾莎莎王团结章晨峰王振中
Owner JIANGSU KANION PHARMA CO LTD
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