CeRNA regulation and control network for early diagnosis or detection of cerebral aneurysm and application of ceRNA regulation and control network

A technology for early diagnosis of cerebral aneurysms, applied in the direction of DNA/RNA fragments, recombinant DNA technology, microbial measurement/inspection, etc., to achieve high detection efficiency and strong pertinence

Pending Publication Date: 2022-07-08
NINGBO FIRST HOSPITAL
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  • CeRNA regulation and control network for early diagnosis or detection of cerebral aneurysm and application of ceRNA regulation and control network
  • CeRNA regulation and control network for early diagnosis or detection of cerebral aneurysm and application of ceRNA regulation and control network
  • CeRNA regulation and control network for early diagnosis or detection of cerebral aneurysm and application of ceRNA regulation and control network

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[0020] 1. GEO data collection of patients with cerebral aneurysm

[0021] The whole analysis work is as figure 1 shown. GEO database (http: / / www.ncbi.nlm.nih.gov / geo), the full name of GENE EXPRESSION OMNIBUS, is a gene expression database created and maintained by the National Center for Biotechnology Information NCBI, brain aneurysm-related mRNA / lncRNA / The miRNA microarray datasets are all from the GEO database. A total of 20 pieces of information were retrieved with the keywords of "cerebralaneurysm / brain aneurysm / Intracranial aneurysm", "Homo sapiens", "Expressionprofiling by array" and "Non-coding RNA profiling by array". Filtering criteria: 1) The sample type is cerebral artery-related tissue; 2) The healthy group must be included; 3) The detection method is microarray chip. Based on the above conditions, there are 6 sets of chip data (mRNA and lncRNA share 5 sets of chip data, miRNA has 1 set of microarray data) were included in the study. Finally, 68 samples were ...

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Abstract

The invention discloses a ceRNA regulation and control network for early diagnosis or detection of cerebral aneurysm and application thereof, and is characterized in that the ceRNA regulation and control network is an lncRNA MIAT-miRNA-17-3p-GALNT10 regulation and control network, an lncRNA MIAT gene is shown as SEQ ID No.1, a miRNA-17-3p gene is shown as SEQ ID No.2, and a GALNT10 gene is shown as SEQ ID No.3. The application of the ceRNA regulation and control network in preparation of drugs and kits for early diagnosis or detection of cerebral aneurysm can be used for early diagnosis or detection of cerebral aneurysm. In early diagnosis or detection of cerebral aneurysm, the molecular marker miRNA-17-3p is low in expression, and MIAT and GALNT10 genes are high in expression; the method has the advantages that the cerebral aneurysm can be conveniently and quickly detected on the molecular level, the detection efficiency is high, the specificity is strong, and the sensitivity is high.

Description

technical field [0001] The invention relates to the technical field of auxiliary diagnosis of cerebral aneurysm, in particular to a ceRNA regulation network for early diagnosis of cerebral aneurysm and its application. Background technique [0002] Intracranial aneurysm (IA) is a common cerebrovascular disease with high morbidity and mortality. IA rupture is the main cause of death, with a fatality rate of 35% and a disability rate of about 30%. Only less than 30% of IA ruptured patients can return to independent life. The traditional diagnosis of cerebral aneurysm is based on imaging methods, and patients often go to the hospital only when they have related symptoms. IA usually has no obvious symptoms before it ruptures, and due to the limitation of imaging diagnostic technology and cost, patients' awareness of active inspection is weak, and 80%-90% of unruptured aneurysms are discovered incidentally. IA is also known as the "time bomb" of the brain. It is very easy to ru...

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IPC IPC(8): C12Q1/6886C12Q1/686C12N15/11
CPCC12Q1/6886C12Q1/686C12Q2600/178C12Q2600/158C12Q2563/107C12Q2545/114
Inventor 黄毅于茜高彤孙杰高翔聂晟
Owner NINGBO FIRST HOSPITAL
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