Method for improving bioavailability of over-the-counter drugs (OTCs) and pharmaceutical drugs

A technology for biological surfaces and drug compounds, applied in the field of improving the bioavailability of over-the-counter drugs (OTC) and pharmaceutical drugs, can solve problems such as increased toxicity and toxicity, and achieve the effect of improving efficacy

Pending Publication Date: 2022-07-08
LOCUS IP CO LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

SDS is toxic to invertebrates and crustaceans; toxicity is increased when combined with glutaraldehyde

Method used

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Embodiment Construction

[0032] The present invention provides materials and methods for improving the bioavailability, stability and / or localization of pharmaceutical and OTC drugs. In particular, the present invention provides therapeutic compositions with biosurfactants of microbial origin for enhancing the efficacy of active ingredients (eg, pharmaceutical compounds). The resulting compositions and methods of the present invention are non-toxic and cost-effective, and, advantageously, may help reduce the use of chemical surfactants in pharmaceutical and OTC pharmaceuticals.

[0033] Further described herein are methods of increasing drug bioavailability using a variety of means, including, for example, increasing drug solubility, elimination half-life, and / or permeability through epithelial tissues; extending drug delivery time periods; and / or increasing drug delivery time to Drug stability prior to subject administration. In specific exemplary embodiments, administration of a composition of the ...

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PUM

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Abstract

The present invention relates to compositions and methods for enhancing the efficacy of pharmaceutical compounds. The present invention utilizes adjuvant compositions comprising one or more microbiologically produced biosurfactants and / or isomers thereof to enhance the bioavailability, stability and localization of a drug in a subject, reduce the total dose required, and improve the pre-administration stability of the drug.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of US Provisional Application Serial No. 62 / 885,233, filed August 10, 2019, the entire contents of which are incorporated herein by reference. Background technique [0003] Bioavailability is critical to the efficacy of a pharmaceutical drug or over-the-counter (OTC) compound. Bioavailability is defined as the amount of an administered compound that reaches circulation in a subject in a constant manner. Intravenous compounds are defined as fully bioavailable compounds; however, there are several major factors that influence the bioavailability of other methods of administration: solubility, stability, and membrane or tissue permeability. In addition, some drugs cannot be localized at the desired site due to their inability to transfer from the systemic circulation via the blood-brain or blood-testis barrier. Each factor has an independent or dependent effect on the amount of prototype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107
CPCA61K9/107A61K47/26A61K47/14A61K47/183A61K31/7056A61K31/7052A61K31/4709A61K31/69A61K31/454A61K31/58A61K31/7068A61K31/704A61K31/517A61K31/616A61K31/192A61K31/155A61K31/445A61K31/426A61K31/55A61K31/568A61K31/53A61K31/4985A61K31/519A61K31/496A61K31/05A61K31/07A61K31/355A61K31/122A61K31/593A61K38/4826A61K9/1075A61K9/127A61K9/51A61K31/4045A61K45/06A61K47/36A61K47/42
Inventor 肖恩·法默肯·阿里贝克
Owner LOCUS IP CO LLC
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