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Composition for preparing burn and wound dressing as well as preparation and preparation method thereof

A wound dressing and composition technology, applied in medical science, bandages, etc., can solve the problems of small skin irritation, oxidative stress response cannot be effectively resolved, wound tissue fluid leakage, etc., to facilitate quality control and facilitate large-scale production , restore the effect of the repair function

Pending Publication Date: 2022-07-15
SHENZHEN BAY LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problem caused by the leakage of wound tissue fluid by using the ability of silk fibroin porous body to absorb exudate, less irritation to the skin and air permeability, but it still cannot effectively solve the oxidative stress response induced by burn wounds.

Method used

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  • Composition for preparing burn and wound dressing as well as preparation and preparation method thereof
  • Composition for preparing burn and wound dressing as well as preparation and preparation method thereof
  • Composition for preparing burn and wound dressing as well as preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1. Preparation of modified silk fibroin solution sample 1

[0055] 1) Take 10 g of silk fibroin fiber, add 100 mL of calcium chloride ternary solution (calcium chloride: water: ethanol = 1:1~5:1~20), dissolve at 80 °C, and dialyze for 3 days. Change deionized water 3 times a day to obtain silk fibroin solution;

[0056] 2) Take 20 mL of the silk fibroin solution obtained in step 1), add 2 mL of EDTA aqueous solution with a concentration of 100 mmol / L to react for 1 h, dialyze for 3 days, and change deionized water 3 times a day to obtain a low-calcium or calcium-free silk fibroin solution Sample 1.

Embodiment 2

[0057] Example 2. Preparation of modified silk fibroin solution sample 2

[0058] 1) Take 10 g of silk fibroin fiber, add 100 mL of lithium bromide solution with a concentration of 10 mol / L, dissolve at 80 °C, dialyze for 3 days, and change deionized water 3 times a day to obtain a silk fibroin solution;

[0059] 2) Take 20 mL of the silk fibroin solution obtained in step 1), add 2 mL of EDTA aqueous solution with a concentration of 100 mmol / L to react for 1 h, dialyze for 3 days, and change deionized water 3 times a day to obtain low-calcium or calcium-free silk fibroin. Solution sample 2.

Embodiment 3

[0060] Example 3. Preparation of modified silk fibroin solution sample 3

[0061] 1) Take 1 g of silk fibroin fiber, add 20 ml of EDTA aqueous solution with a concentration of 100 mmol / L to react for 24 hours, dialyze for 3 days, change deionized water 3 times a day, and dry at 50 ℃ to obtain low-calcium or calcium-free silk fibroin fiber;

[0062] 2) Take 10 g of low-calcium or calcium-free silk fibroin fibers obtained in step 1), add 100 mL of lithium bromide solution with a concentration of 10 mol / L, react at 80 °C for 24 h, dialyze for 3 days, and change deionized water 3 times a day to obtain low Calcium or calcium-free silk fibroin solution sample 3.

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Abstract

The invention belongs to the technical field of medical drugs, and particularly relates to a composition for preparing a burn wound dressing and a preparation and a preparation method thereof. According to the burn and wound dressing, silk fibroin serves as an antioxidant and is loaded to a framework of chitosan-water absorption molecules, and the porous asymmetric burn and wound dressing with the antioxidant and moisturizing functions is prepared. The burn and wound dressing consists of silk fibroin, a skeleton and an auxiliary material in a mass ratio of 1: (2-10): (0.1-5), the framework is a chitosan-water absorption polymer framework; the mass ratio of the chitosan to the water-absorbing polymer is 1: (0.1-5). The burn wound dressing disclosed by the invention can promote the healing of a chronic wound surface difficult to heal in an oxidative stress microenvironment, and is a novel composite dressing integrating the advantages of high moisture retention, high strength, air permeability, barrier property, easy uncovering property and the like. The dressing is prepared through freeze-drying, the preparation process is simple, the cost is low, the treatment effect is outstanding, the safety of burns and wounds is good, and the dressing has remarkable medical value and industrialization potential.

Description

technical field [0001] The invention belongs to the field of medicine for burn wounds, and in particular relates to a composition for preparing burn wound dressings, preparations and preparation methods thereof. Background technique [0002] Burns are one of the major catastrophic events in humans and the fourth most common trauma worldwide. Severe hypermetabolic response and damage to antioxidant and cellular defense mechanisms after burn, local or systemic oxidative stress has a very important impact on the recovery of the patient's wound, which will cause the burn wound to be in a state of long-term inflammatory infiltration, non-healing and scarring of the wound. , and even lead to serious consequences such as multiple organ failure. [0003] It is well known that oxidative stress is an excess of reactive oxygen species (ROS) that wreak havoc on DNA, lipids, proteins and carbohydrates at the wound site. Thus, unbalanced ROS alter cellular functions, leading to abnormal...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0085A61L26/008A61L26/0066A61L26/0004A61L26/0047A61L26/0023A61L2300/404A61L2300/412A61L2300/106A61L2300/252C08L5/08C08L89/00
Inventor 彭琴钱智勇
Owner SHENZHEN BAY LAB
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