Anhydrous root canal disinfectant substrate with high flowability, disinfectant applying same and application

A high-fluidity, disinfectant technology, applied in the field of oral care, can solve the problems of not easy to take out or flush out, the product is not ideal, not easy to disperse, etc. The effect of maintaining antibacterial properties

Pending Publication Date: 2022-07-22
昆明青橙医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The clinical use of calcium hydroxide has the following problems: ①. The two-component calcium hydroxide paste commonly used in clinical practice is not easy for doctors to prepare; ②. It is not easy to disperse, and it is often not easy to completely remove or flush out the root canal after filling; ③ 1. It is easy to absorb carbon dioxide to form calcium carbonate that is ineffective for root canal treatment, and it is difficult to remove; 4. Most clinically used calcium hydroxide pastes need to be prepared with water. Although they can quickly form a high pH environment in the root canal, they cannot Some products are not ideal for long-term high pH environment in the root canal

Method used

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  • Anhydrous root canal disinfectant substrate with high flowability, disinfectant applying same and application
  • Anhydrous root canal disinfectant substrate with high flowability, disinfectant applying same and application
  • Anhydrous root canal disinfectant substrate with high flowability, disinfectant applying same and application

Examples

Experimental program
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Effect test

Embodiment 1

[0118] The following raw materials are used to prepare by mass percentage: calcium hydroxide is 10-60%, zirconia is 15-35%, polyoxyethylene ether (60) hydrogenated castor oil is 0.1-5.0%, polyvinylpyrrolidone is 0.5-5.0%, Polyethylene glycol 200 is the balance.

[0119] Preparation:

[0120] 1. Take the above raw materials according to the mass ratio, first put the polyvinylpyrrolidone into the polyethylene glycol 200 to fully swell, and obtain a polyvinylpyrrolidine / polyethylene glycol 200 homogeneous solution A of not more than 20%;

[0121] ②. Add calcium hydroxide, zirconium oxide, polyoxyethylene ether (60) hydrogenated castor oil into the homogeneous solution A and fully homogeneously disperse it with a homogenizer, that is, it is obtained.

Embodiment 2

[0123] The raw materials of 8 formulas and their mass ratios are listed in Table 3. For each formula, the raw materials are obtained according to the mass ratios, and a homogeneous paste is obtained by the preparation method of Example 1.

[0124] Table 3 formula raw materials and their mass percentage ratio

[0125]

[0126]

[0127] In Table 3, RH60: polyoxyethylene ether (60) hydrogenated castor oil; PVP: polyvinylpyrrolidone; PEG-200: polyethylene glycol 200.

[0128] PEG-200 in the formula can be replaced by PEG-400 or PEG-600. RH60 can be replaced by other polyoxyethylene ether hydrogenated castor oil with different molecular weights, such as polyoxyethylene ether (40) hydrogenated castor oil.

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Abstract

The invention discloses an anhydrous root canal disinfectant substrate with high flowability, a disinfectant applying the same and application, and the substrate is prepared from the following components in percentage by mass: 0.5 to 5.0 percent of polyvinylpyrrolidone, 0.1 to 5.0 percent of nonionic or cationic surfactant, and 32.0 to 85.0 percent of polyethylene glycol with the molecular weight of 200 to 600. According to the invention, polyvinylpyrrolidone, a nonionic or cationic surfactant and polyethylene glycol with specific molecular weight form a matrix, then hydroxide of alkaline earth metal is added to prepare the available anhydrous root canal disinfection paste, and the disinfection paste is very easy to disperse in water and can be rapidly flushed out before root canal filling; meanwhile, the disinfectant can effectively control diffusion of OH <-> for a long time, so that the strong alkaline environment of the root canal is maintained, the effect of maintaining the antibacterial property in the root canal for a long time is achieved, and the defects existing in the application process of the prior art are overcome.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to an anhydrous root canal disinfectant matrix with high fluidity and a disinfectant and application thereof. Background technique [0002] Root canal therapy, also known as endodontic treatment, is a procedure used in dentistry to treat pulp necrosis and root infection. Root canal therapy consists of three stages: root canal preparation, disinfection and filling. Due to the complexity of the root canal system, conventional mechanical preparation can only remove most of the infected tissue and cannot achieve complete removal, and the bacteria and toxins remaining in the deep dentinal tubules and collateral root canals rely solely on manual instruments or machine-used nickel-titanium instruments. Still hard to clear. Therefore, root canal disinfection plays a key role, so a disinfectant is needed to effectively penetrate and sterilize the root canal. [0003] Calcium hydroxide i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/52A61K6/61A61K6/69A61K6/71A61K6/60
CPCA61K6/52A61K6/61A61K6/69A61K6/71A61K6/60
Inventor 张磊孙宇陆可望吴拓江史晓军
Owner 昆明青橙医疗科技有限公司
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