The invention relates to a
proton pump inhibitor frozen
powder injection agent and a preparation method thereof. The
proton pump inhibitor frozen
powder injection agent prepared by the method can be taken as a
medicine for treating gastric ulcer,
duodenal ulcer, erosive gastroesophageal
reflux disease,
helicobacter pylori and Zollinger-Ellison Syndrome. The
proton pump inhibitor frozen
powder injection agent is prepared through taking a
proton pump inhibitor as an
active ingredient, adopting crystallized
filtration, freezing and
drying. The preparation process comprises the following steps of: adding water for injection and alkali to the
proton pump inhibitor, stirring to dissolve and mix uniformly; performing the crystallized
filtration; after measuring the content, adjusting pH value of filtrate; using the water for injection for fixing volume and a millipore filter with 0.22 mu m for
filtration; filling, partially arranging corks, arranging in trays, freezing out, pressing the corks, taking out from boxes, rolling openings, checking quality and packaging. The prepared
proton pump inhibitor frozen
powder injection agent has excellent re-dissolving performance, is more stable when used together with transfusion in clinical use, can not separate out, and has better inspection result for visible foreign matters and insoluble particles.