Sanbai soup carrier and preparation method thereof

The technology of Sanbai Decoction and transfer body is applied in the field of Sanbai Decoction transfer body and its preparation, which can solve the problems of large consumption volume, easy mildew after long-term storage, cumbersome decoction, etc., achieve high bioavailability, improve drug efficacy, The effect of improving bioavailability

Active Publication Date: 2022-07-22
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the shortcomings of "Sanbai Decoction" traditional decoction such as cumbersome decoction, easy mildew after long-term storage, inconvenient to carry, large volume of taking, and uncomfortable taste, the present invention has no gastrointestinal irritation, No hepatic first-pass effect, convenient administration, skin targeting and other advantages, the traditional oral decoction "Sanbai Decoction" has been made into nanotransfersomes (flexible liposomes)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sanbai soup carrier and preparation method thereof
  • Sanbai soup carrier and preparation method thereof
  • Sanbai soup carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:

[0044] Prepare according to the following components by weight:

[0045] Egg yolk lecithin 30mg;

[0046] Sanbaitang extract 1.0g;

[0047] Sodium cholate 2.0mg;

[0048] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.

[0049] Take 30.0 mg of egg yolk lecithin and dissolve it in anhydrous ethanol by ultrasonic to prepare solution A with a mass concentration of 15.0 mg / mL containing egg yolk lecithin;

[0050] Take 2.0 mg of sodium cholate and 1.0 g of Sanbai Decoction extract and dissolve them in a phosphate buffer solution with a pH value of 7.4 to prepare solution B with a mass concentration of 0.1 mg / mL of Sanbai Decoction extract;

[0051] The solution B was placed in a water bath at 40°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was uniformly added dr...

Embodiment 2

[0053] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:

[0054] Prepare according to the following components by weight:

[0055] Egg yolk lecithin 40.0mg;

[0056] Sanbaitang extract 1.0g;

[0057] Sodium cholate 4.0mg;

[0058] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.

[0059] Take 40.0 mg of egg yolk lecithin and dissolve it in anhydrous ethanol by ultrasonic to prepare solution A with a mass concentration of 20.0 mg / mL containing egg yolk lecithin;

[0060] Take 4.0 mg of sodium cholate and 1.0 g of Sanbai decoction extract and dissolve them in a phosphate buffer solution with a pH value of 7.4 to prepare a solution B with a mass concentration of 0.2 mg / mL of sodium cholate;

[0061] The solution B was placed in a water bath at 30°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was evenly added dropwise whil...

Embodiment 3

[0063] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:

[0064] Prepare according to the following components by weight:

[0065] Egg yolk lecithin 50.0mg;

[0066] Sanbaitang extract 1.0g;

[0067] Sodium cholate 6.0mg;

[0068] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.

[0069] Take 50.0 mg of egg yolk lecithin, dissolve it in absolute ethanol by ultrasonic, and prepare solution A with a mass concentration of 25.0 mg / mL of egg yolk lecithin;

[0070] Take 6.0 mg of sodium cholate and 1.0 g of Sanbai decoction extract, dissolve them in phosphate buffer solution with a pH value of 7.4, and prepare solution B with a mass concentration of sodium cholate of 0.3 mg / mL;

[0071] The solution B was placed in a water bath at 50°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was evenly added dropwise while stirring. A...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a Sanbai soup carrier and a preparation method thereof. Comprising the following main steps: dissolving 30-50 parts of egg yolk lecithin in ethanol to prepare a solution A; dissolving 2-6 parts of sodium cholate and 1000-2000 parts of Sanbai decoction extract in a phosphate buffer solution to prepare a solution B; under the hydration temperature of 30-50 DEG C and the action of magnetic stirring, slowly dropwise adding the solution A into the solution B, and optimizing the component contents of egg yolk lecithin, the Sanbai decoction extract and sodium cholate to prepare the Sanbai decoction nanometer carrier with light yellow opalescence. As a novel Sanbai decoction nano transdermal preparation, the carrier can penetrate through the cuticle of the skin and be absorbed by the corium layer, and has skin targeting property. Compared with the traditional decoction, the carrier accelerates the percutaneous penetration rate of paeoniflorin and glycyrrhizic acid with higher content in the Sanbai decoction, has a slow release characteristic, improves the bioavailability of the traditional Sanbai decoction, and can ensure that the Sanbai decoction has the effects of whitening, removing freckles and removing acnes.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine nano preparations, in particular to a transfer body of Sanbai Decoction and a preparation method thereof. Background technique [0002] "Sanbai Decoction" comes from Li Qi's "Introduction to Medicine Volume 3: Medicine for Typhoid Febrile Diseases" in Ming Dynasty. It was initially used to treat typhoid deficiency and troublesomeness, and later found that it can nourish qi, nourish blood, whiten and moisturise the skin, and it became popular among the people. This recipe is well-matched, suitable for rough skin, chlorosis, chloasma, hyperpigmentation, acne, pimples, acne, etc. caused by deficiency of qi and blood (endocrine disorders). The basic theory of traditional Chinese medicine believes that the lustrousness of human skin is closely related to the function of the viscera. Therefore, the prescription starts with the functions of reconciling qi and blood, and regulating t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/65A61K36/71A61K9/10A61K47/24A61K47/28A61P17/00A61P17/16
CPCA61K36/284A61K36/71A61K36/65A61K36/076A61K36/484A61K9/0014A61K47/24A61K47/28A61K9/10A61P17/16A61P17/00A61K2300/00
Inventor 张彩云肖垚垚葛宗瑞马继浩盛菲涵钱广荣
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap