Sanbai soup carrier and preparation method thereof
The technology of Sanbai Decoction and transfer body is applied in the field of Sanbai Decoction transfer body and its preparation, which can solve the problems of large consumption volume, easy mildew after long-term storage, cumbersome decoction, etc., achieve high bioavailability, improve drug efficacy, The effect of improving bioavailability
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Embodiment 1
[0043] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:
[0044] Prepare according to the following components by weight:
[0045] Egg yolk lecithin 30mg;
[0046] Sanbaitang extract 1.0g;
[0047] Sodium cholate 2.0mg;
[0048] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.
[0049] Take 30.0 mg of egg yolk lecithin and dissolve it in anhydrous ethanol by ultrasonic to prepare solution A with a mass concentration of 15.0 mg / mL containing egg yolk lecithin;
[0050] Take 2.0 mg of sodium cholate and 1.0 g of Sanbai Decoction extract and dissolve them in a phosphate buffer solution with a pH value of 7.4 to prepare solution B with a mass concentration of 0.1 mg / mL of Sanbai Decoction extract;
[0051] The solution B was placed in a water bath at 40°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was uniformly added dr...
Embodiment 2
[0053] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:
[0054] Prepare according to the following components by weight:
[0055] Egg yolk lecithin 40.0mg;
[0056] Sanbaitang extract 1.0g;
[0057] Sodium cholate 4.0mg;
[0058] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.
[0059] Take 40.0 mg of egg yolk lecithin and dissolve it in anhydrous ethanol by ultrasonic to prepare solution A with a mass concentration of 20.0 mg / mL containing egg yolk lecithin;
[0060] Take 4.0 mg of sodium cholate and 1.0 g of Sanbai decoction extract and dissolve them in a phosphate buffer solution with a pH value of 7.4 to prepare a solution B with a mass concentration of 0.2 mg / mL of sodium cholate;
[0061] The solution B was placed in a water bath at 30°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was evenly added dropwise whil...
Embodiment 3
[0063] A kind of Sanbaitang transfer body, comprising the preparation of following process steps:
[0064] Prepare according to the following components by weight:
[0065] Egg yolk lecithin 50.0mg;
[0066] Sanbaitang extract 1.0g;
[0067] Sodium cholate 6.0mg;
[0068] Wherein, the Sanbai Decoction extract contains substances such as glycyrrhizic acid and paeoniflorin with relatively high contents.
[0069] Take 50.0 mg of egg yolk lecithin, dissolve it in absolute ethanol by ultrasonic, and prepare solution A with a mass concentration of 25.0 mg / mL of egg yolk lecithin;
[0070] Take 6.0 mg of sodium cholate and 1.0 g of Sanbai decoction extract, dissolve them in phosphate buffer solution with a pH value of 7.4, and prepare solution B with a mass concentration of sodium cholate of 0.3 mg / mL;
[0071] The solution B was placed in a water bath at 50°C, and the solution B was magnetically stirred at 300 r / min, and the solution A was evenly added dropwise while stirring. A...
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