Method for predicting tumor treatment prognosis by establishing inflammatory cell infiltration model based on radiomics

A technology of cell infiltration and radiomics, applied in the field of tumor treatment, can solve problems such as long time, trauma, tumor metastasis, etc.

Pending Publication Date: 2022-07-26
吴式琇 +1
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Problems solved by technology

[0004] (1) Invasive, increasing the risk of metastasis: there is trauma in the biopsy process, which may easily cause tumor metastasis along the cavity
[0005] (2) Long time: the specimen needs to be processed before the test, so it takes at least a week to get the result
[0006] (3) Irreproducibility: Due to the existence of multiple risks, it is not recommended for patients to take multiple biopsies for detection

Method used

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  • Method for predicting tumor treatment prognosis by establishing inflammatory cell infiltration model based on radiomics
  • Method for predicting tumor treatment prognosis by establishing inflammatory cell infiltration model based on radiomics
  • Method for predicting tumor treatment prognosis by establishing inflammatory cell infiltration model based on radiomics

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Embodiment

[0034] refer to Figure 1-5 As shown, a method for establishing an inflammatory cell infiltration model based on radiomics to predict the prognosis of tumor treatment includes the following steps:

[0035] (1) Obtain gene detection sequences from patient tumor biopsies, use analysis algorithms to analyze nucleic acid sequence RNA-seq data to obtain various inflammatory cell infiltration ratios, and obtain immune cell infiltration data as the output of subsequent model training.

[0036] Further, the analysis algorithm is the TIMER algorithm. The TIMER algorithm obtains different percentages of inflammatory cell infiltration through nucleic acid sequence RNA-sque, and selects one of the percentages of cells as the output result of the training of the radiomics model.

[0037] In this step, the current evaluation algorithms for immune infiltration include TIMER, CIBERS ORT, quanTIseq, xCell, MCP-counter, etc. Many of these algorithms need to download their own code to implement,...

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Abstract

The invention relates to the technical field of tumor treatment, in particular to a method for predicting tumor treatment prognosis by establishing an inflammatory cell infiltration model based on iconomics, and the method comprises the following steps: obtaining an immune infiltration proportion through patient genome data, and then performing iconomics analysis or neural network learning with corresponding iconomics data to obtain an immune infiltration model; an output result is a corresponding immune infiltration result, an immune cell infiltration model is established, finally, the model is used for predicting an image of a new patient, the infiltration condition of the new patient is obtained, and compared with a traditional method, the method has the advantages of being noninvasive, rapid, repeatable and the like; a completely noninvasive means is provided for judging immune change and prognosis conditions in the tumor disease treatment process.

Description

technical field [0001] The invention relates to the technical field of tumor treatment, in particular to a method for establishing an inflammatory cell infiltration model based on radiomics to predict the prognosis of tumor treatment. Background technique [0002] Tumors refer to new organisms formed by the proliferation of local tissue cells under the action of various tumorigenic factors. [0003] Studies have shown that there is a great correlation between the infiltration of inflammatory cells in tumors and the prognosis of tumor radiotherapy and chemotherapy. Currently, laboratory testing of tumor tissue by biopsy is the only criterion for obtaining inflammatory cell infiltration within the tumor. However, this method has the following problems: [0004] (1) It is invasive and increases the risk of metastasis: there is trauma in the biopsy process, which is likely to cause tumor metastasis along the lumen. [0005] (2) Long time: The specimen needs to be processed be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/50G16H30/00G16H50/70G16B40/00G16B20/30
CPCG16H50/50G16H30/00G16H50/70G16B40/00G16B20/30
Inventor 毕苏艳吴式琇
Owner 吴式琇
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