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Application of litsea cubeba essential oil liposome in anti-inflammation and acne removal

A technology of oily liposome and Litsea Cubeba, applied in liposome loaded with Litsea Cubeba essential oil, anti-inflammatory and anti-acne, to improve embedding rate, expand application prospects, and improve water solubility

Active Publication Date: 2022-08-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no case of modifying and applying LCEO at present.

Method used

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  • Application of litsea cubeba essential oil liposome in anti-inflammation and acne removal
  • Application of litsea cubeba essential oil liposome in anti-inflammation and acne removal
  • Application of litsea cubeba essential oil liposome in anti-inflammation and acne removal

Examples

Experimental program
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Embodiment 1

[0044] Embodiment 1: the preparation of Radix japonica essential oil (LCEO) liposome, comprises the following steps:

[0045] 1), take by weighing 30.0mg soybean lecithin, weigh 1.67mg cholesterol, make soybean lecithin and cholesterol mass ratio 18:1, dissolve soybean lecithin and cholesterol in 1.0mL absolute ethanol, ultrasonically mix for 5min for later use, as Ethanol phase.

[0046] 2), add 0.002 mg of sodium dodecyl sulfate (SDS) as an emulsifier to 9.0 mL of PBS buffer with a concentration of 0.1 mmol / L, and adjust the pH to 7.4 as an aqueous phase.

[0047]3), take 5.0mg Radix chinensis essential oil (LCEO) and be dissolved in step 1) gained in all ethanol phase, under 400r / min magnetic stirring condition, be quickly injected into step 2) gained all water phase, continue in The hydration reaction was carried out for 40 min under the condition of magnetic stirring at 400 r / min to obtain LCEO liposome solution (liposome solution loaded with essential oil of C. chinensi...

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Abstract

The invention relates to the field of medicines and daily chemicals, in particular to application of litsea cubeba essential oil-loaded lipidosome in anti-inflammatory and acne-removing aspects. The invention discloses application of litsea cubeba essential oil liposome in preparation of anti-inflammatory and acne-removing daily chemical products / medicines. The preparation method of the litsea cubeba essential oil liposome comprises the following steps: dissolving soybean lecithin and cholesterol in ethanol; taking as an ethanol phase; preparing a PBS (Phosphate Buffer Solution) with the concentration of 0.1 mmol / L, and adjusting the pH to 7.4 + / -0.4 to serve as a water phase; dissolving the litsea cubeba essential oil in an ethanol phase, injecting into the water phase under a magnetic stirring condition, and carrying out a hydration reaction for 40 + / -10 min to obtain a litsea cubeba essential oil-loaded liposome solution.

Description

technical field [0001] The invention relates to the fields of medicinal use and daily chemicals, in particular to the application of liposomes loaded with essential oil of Radix chinensis in anti-inflammatory and acne-removing. Background technique [0002] Acne is a common chronic inflammatory skin disease that occurs in the hair follicles and sebaceous glands. It may last for many years and leave permanent scars and pigmentation. It not only brings physical discomfort to patients, but even affects their mental health. At present, hormones, antibiotics and retinoic acid drugs are often used in clinical treatment of acne. These drugs have ideal therapeutic effects, but they are prone to produce some toxic side effects on the human body, and even make the skin dependent; and antibiotic treatment lacks bacterial specificity and is easy to use Bacteria develop resistance. Natural plant extracts from plants such as Radix chinensis, which have acne-removing effects, will have a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K36/54A61K8/14A61K8/92A61P17/10A61P29/00A61Q19/00
CPCA61K36/54A61K8/922A61K8/14A61K9/127A61P17/10A61P29/00A61Q19/00Y02A50/30
Inventor 沈建福苏远刘尧
Owner ZHEJIANG UNIV
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