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Drop pills for treating oral disease

A technology for oral diseases and dripping pills, applied in the directions of pill delivery, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of inconvenient application for the elderly and children, increasing the incidence of adverse reactions, and inability to achieve quantitative drug delivery. , to improve bioavailability, avoid first-pass effect, and avoid gastrointestinal irritation symptoms

Inactive Publication Date: 2006-11-15
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the limitations of medicines and existing technologies, most of the existing medicinal sprays cannot be administered quantitatively, so it is difficult to accurately control the dose during operation, which directly affects the therapeutic effect, and may be caused by improper operation. Cause waste and increase the incidence of adverse reactions; the use of this dosage form is limited, especially for the elderly and children; the manufacturing cost of this dosage form is high, which objectively increases the medical burden of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Now with the test of several groups of specific examples and the results thereof, the preparation method of Jinhoujian dripping pills of the present invention will be further described.

[0029] Group 1: Tests with a single matrix

[0030] [formula]

[0031] (Preparation is carried out according to the process given in [Preparation Method of Dripping Pill Raw Materials], and the dry powder containing the active ingredient of the medicine can be obtained.)

[0032] 1. Raw materials - dry powder containing active pharmaceutical ingredients prepared by the previous method;

[0033] 2. Substrate: polyethylene glycol 2000、4000、6000、8000、10000、20000 , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0034] 3. Proportioning (in g, in parts by weight): drug extract: matrix = 1:1 to 1:9.

[0035] [test results]

[0036] Test 1: In ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition with the functions of expelling wind and detoxification, reducing swelling and relieving pain, clearing throat and relieving throat, and particularly relates to a pharmaceutical composition formulated on the basis of the formulation of Jinhoujian Spray and modified dosage forms. Oral preparations. The purpose of the present invention is to supplement the deficiencies of the existing oral pharmaceutical preparations for sore throat, dry throat, red and swollen throat, swollen gums, and oral ulcers caused by wind-heat, and to provide a drug with high bioavailability, rapid drug release, and fast Jinhoujian dripping pills with obvious effect, less toxic and side effects, no pollution and lower production cost. The dropping pill preparation involved in the present invention is prepared through the dropping pill technology on the basis of the Jinhoujian spray technology.

Description

technical field [0001] The invention relates to a pharmaceutical composition which has the functions of expelling wind and detoxification, reducing swelling and relieving pain, clearing throat and relieving throat, and is used for sore throat, dry throat, red and swollen throat, swollen gums and oral ulcers caused by wind-heat. Based on the formula of Jinhoujian Spray, it is an oral preparation of pharmaceutical composition reformed through dosage form. Background technique [0002] According to the formula and extraction process given in the national drug standard WS-10293 (ZD-0293)-2022, Jinhoujian Spray is prepared from Aina sesame oil, Daguojiangzi oil, menthol, and glycyrrhizic acid monosodium glutamate The pharmaceutical composition prepared from the amine salt is a very effective medicine for treating sore throat, dry throat, red and swollen throat, swollen gums and oral ulcers caused by wind-heat. Because of its obvious therapeutic effect, it has been made into a sp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/28A61K31/045A61P1/02
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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