Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases

The technology of extract and roselle is applied in the field of roselle extract for preparing drugs for inhibiting cerebral cardiovascular disease and atherosclerosis, and can solve the problems of easy oxidation of LDL and the like

Inactive Publication Date: 2006-11-15
AIKEN BIOTECHNOLOGY INT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, plasma LDL contains too little antioxidants, too high a proportion of polyunsaturated fatty acids (PUFAs) or too high a concentration of Cu in plasma ++ , Fe ++ And other factors, will lead to easy oxidation of LDL, and it is the most important positive risk factor for atherosclerosis

Method used

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  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases
  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases
  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Example 1: Inhibitory effect on LDL oxidation

[0024] When LDL is not oxidized, its molecular weight is small, so it moves faster in gel electrophoresis experiments at the same potential. When LDL is oxidized, its molecular weight is larger, and relatively slower in gel electrophoresis experiments at the same potential. We added different concentrations of roselle extract (0.5, 1, 2mg / ml) and 10μM copper sulfate (CuSO 4 ) and 100mM sodium nitroprusside (Sodium Nitroprusside (SNP)) together at 37 degrees Celsius to induce LDL oxidation for 24 hours, it can be found that the higher the concentration of the roselle extract, the more significant the effect of inhibiting LDL oxidation, The faster the electrophoretic movement rate. Adding Roselle extract to inhibit LDL oxidation after SNP-induced LDL oxidation, compared with CuSO 4 After inducing LDL oxidation, the effect of adding roselle flower extract to inhibit LDL oxidation is similar, but the effect is less significa...

example 2

[0034] Example 2: Lowering Triglyceride and Cholesterol in Plasma

[0035] experimental animals

[0036] The experimental animals used in the present invention are New Zealand white rabbits (about 2-2.2 kilograms in body weight) and Sprague-Dawley rats (about 200-220 grams in body weight). A total of 30 rabbits were divided into 5 groups, 1 in each cage, 150g diet per day, among which 3 groups were fed with 95.7% solid food, 3% lard and 1.3% cholesterol for 10 weeks, which could induce atherosclerosis, The roselle extract test group then added 1% or 0.5% roselle extract; a total of 24 rats were divided into 4 groups, 6 in each cage, and 25g diet per day, of which three groups were fed with 95.7% solid food, 3 % lard and 1.3% cholesterol, fed for 12 weeks, can induce atherosclerosis, and the roselle extract test group was added with 1% or 2% roselle extract.

[0037] The rabbits were divided into 5 groups, 6 in each group. The first group was fed with normal diet, the second ...

example 3

[0039] Example 3: Inhibition of atherosclerosis

[0040] The deposition of endothelial oil in arteries is the leading stage of atherosclerosis, that is, if the deposition of endothelial oil in arteries reaches a certain amount, it will often lead to the occurrence of atherosclerosis. The large thoracic artery of the rabbit in Example 2 was stained to observe the situation of oil deposition. The results showed that the arterial endothelium of the high-cholesterol diet group had a lot of oil deposition, but with the addition of roselle extract, the oil deposition was significantly reduced. The result is as Figure 7 shown. It has been confirmed that Roselle extract can inhibit the occurrence of atherosclerosis and cerebrovascular diseases.

[0041] We also took the arteries of the rabbits in Example 2 for tissue sections, and found that the arteries of the rabbits fed a high-cholesterol diet supplemented with 0.5% and 1% roselle extract and the arteries of rabbits fed a norma...

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Abstract

The present invention has discovered that the extract of roselle can reduce triglyceride and cholesterol in blood plasma, inhibit the oxidation of low-density lipoprotein, reduce the oil deposition of arterial endothelium, and improve the phenomenon of smooth muscle migration caused by foam cells formed on the blood vessel wall, etc. The use of this kind of roselle flower extract as the main component provides the use of drugs for inhibiting cerebrovascular diseases.

Description

technical field [0001] The present invention relates to a new application of the extract of the roselle flower, more specifically, it relates to the use of the extract of the roselle flower for preparing drugs for inhibiting cerebrovascular diseases and atherosclerosis. Background technique [0002] In the past, hibiscus tea was used by folks for antipyretic, antihypertensive and treatment of liver diseases. However, no one really understands that the roselle extract has the function of inhibiting cerebrovascular diseases and atherosclerosis, and the present invention lies in the discovery of this new use. [0003] According to research, in recent years, cerebrovascular disease and heart disease have ranked among the top causes of death. Although both cerebrovascular disease and heart disease are caused by the interaction of multiple factors, according to many research data, atherosclerosis is the leading cause of death. The leading cause of these va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/06A61P9/10
Inventor 王朝钟
Owner AIKEN BIOTECHNOLOGY INT CO LTD
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