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Nutritional composition intended for specific gastro-intestinal materation in premature mammals

A nutritional composition, mammalian technology, for use in gastrointestinal maturation. areas, able to solve problems such as unclear

Inactive Publication Date: 2002-04-03
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not clear whether this rapid uptake translates into better nitrogen utilization due to conflicting data from studies showing conflicting results (Collin-Vidal et al; 1994; Endocrinol. Metab., 30, E907-914)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] whole protein

[0039] 5 kg of whey protein (obtained from Meggle GmbH under the trade name Globulal 80) was dispersed in demineralized water at 55°C to obtain a protein concentration (N*6.38) of 10 wt%. The pH of the dispersion was adjusted by adding 190 g of calcium hydroxide and the dispersion was cooled to room temperature. The protein was then dried by freeze drying and packed into metal cans.

[0040] The degree of hydrolysis of the whole protein was about 4.41% and the non-protein nitrogen concentration was about 1.1% of the total nitrogen.

[0041] Hydrolyzate 1

[0042] 6.25 kg of whey protein (from Meggle GmbH) were dispersed in 50 liters of demineralized water at 55°C. The pH of the dispersion was adjusted to 8.2 by adding 1.8 liters of 2M Ca(OH)2. The protein was then hydrolyzed with 30 g of trypsin (salt-free trypsin with an activity of 6.8 AU / g and a chymotrypsin content of less than 5% from Novo Nordisk Ferment AG, Dittigen, Switzerland). The hydroly...

Embodiment 2

[0053] In order to obtain a nutritional composition specific for gastrointestinal maturation of premature mammals, the following mixture was prepared:

[0054] i) 14.5g total protein content / 100g powder:

[0055] 10% of the hydrolyzate 2 prepared as in Example 1,

[0056] 40% of the hydrolyzate 3 prepared as in Example 1,

[0057] 50% whole protein (containing 1ppm TGFβ2),

[0058] ii) 26g fat / 100g powder:

[0059] 40% Medium Chain Triglycerides

[0060] 60% long-chain triglycerides

[0061] iii) 53.6g carbohydrates / 100g powder

[0062] 65% lactose

[0063] 35% maltodextrin

[0064] iv) and meet the daily requirements of vitamins, minerals.

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PUM

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Abstract

A nutritional enteral composition intended for favoring the growth and maturation of non-mature gastro-intestinal tracts of young mammals, which contains as a protein source a mixture of dietary protein hydrolysates and intact proteins being partly in the form of bioactive peptides.

Description

field of invention [0001] The present invention relates to an enteric composition containing peptides of suitable size, biologically active peptides, whole protein, and free amino acids, the composition is especially aimed at the gastrointestinal maturation of premature mammals. Background of the invention [0002] Nutritional compositions based on hydrolysates of proteins such as milk or soy are commonly used in infant and clinical nutrition, and especially in hypoallergenic prescriptions and prescriptions for patients with various intestinal absorption problems. It is also known to use free amino acids in nutritional compositions, eg for patients with specific diseases or conditions such as enteritis, intractable diarrhoea, transient intestinal complications and the like. Thus, amino acids are used either alone or in combination with proteins or protein hydrolysates. Protein hydrolyzates or free amino acid mixtures are also mainly used in special cases such as allergies t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23J3/00A23J3/34A23L1/30A23L1/304A23L1/305A23L33/15
CPCA23L1/3053A23J3/344A23J3/343A23L1/3056A23L33/18A23L33/19A61P1/00
Inventor C·L·加西亚-罗德纳斯P·A·菲诺特J·C·麦雷O·巴莱夫雷A·唐尼特-胡赫斯F·哈施克
Owner SOC DES PROD NESTLE SA
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