Ginseng total saponin or monomer saponin RbI vaccine immunological adjuvant application

Abstract

The present invention discloses an application of ginseng total saponin or monomer saponin Rb1 as vaccine immunologic adjuvant. The ginseng total saponin or monomer saponin Rb1 and aluminium hydroxide are mixed and used as vaccine immunologic adjuvant, and as compared with traditional aluminium hydroxide adjuvant said invention possesses the following advantages: (1) its side effect is less; (2) said vaccine can be stored under the condition of frozen low-temp. and it can prolong effective period of vaccine; (3) its method is simple and convenient, its quality is easy to be controlled; and (4) it can induce body to produce higher humoral immunity response.

Description

technical field [0001] The invention relates to the use of total ginsenosides or monomeric saponin Rb1 as a vaccine immune adjuvant. Background technique [0002] When vaccine adjuvants are used in combination with antigens, they can enhance the body's immune response to antigens, and are widely used in vaccine production. How to apply immune adjuvants to improve the effect of immunization is a hot spot in modern medical research. Since Glenny used aluminum hydroxide glue as an immune adjuvant in the 1920s, aluminum hydroxide adjuvant is still the only FDA-approved adjuvant that can be used in humans. But this type of adjuvant has many disadvantages, for example: 1) it mainly improves the humoral immune response, but has little effect on the cellular immune response; 2) because it increases the production of IgE antibodies, it is easy to cause allergic reactions; 3) the local irritation is relatively low. Big. (1，3) In recent years, various countries...

AI Technical Summary

Problems solved by technology

For example, oil-emulsion adjuvants have been widely used in veterinary medicine in my country, but because of local irritation and difficult degradation in the body, many developed countries prohibit their use on food animals.

In order to promote the export of animal products in my country, the use of oil adjuvants will be restricted accordingly

Artificially synthesized muramyl dipeptide (MDP) has a good adjuvant effect, which is still in the research stage

Quil-A (a saponin extracted from Quillaba bark) has a strong adjuvant effect, but it cannot be used clinically because of its toxic effects and local reactions

(2) There are reports of propolis adjuvants in my country, but the composition of propolis is extremely complex and difficult to control the quality. Currently, it is only used in some animal vaccines

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