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Prepn. and application of nano particle, nano microballoon and biological fuorescent probe

A technology of nanoparticles and fluorescent probes, applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve problems such as high risk, achieve low risk, increase fluorescence intensity, and improve chemical environment adaptability

Inactive Publication Date: 2003-01-08
高明远
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  • Abstract
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Problems solved by technology

However, the experimental operation of the TOPO method has a very high risk, especially the metal-organic compound as a source of cadmium is very toxic

Method used

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  • Prepn. and application of nano particle, nano microballoon and biological fuorescent probe
  • Prepn. and application of nano particle, nano microballoon and biological fuorescent probe
  • Prepn. and application of nano particle, nano microballoon and biological fuorescent probe

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Experimental program
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Embodiment Construction

[0049] 1. Synthesis of CdTe nanoparticles:

[0050] Cd 2+ : Te 2- :HSCH 2 CH 2 NH 2 =1:0.4:2.5

[0051] Concentration: [Cd 2+ ]=10 -3 M; Acidity: pH=7.0; Reaction temperature: T=room temperature+reflux; Reflux time: t=5 minutes-5 days, in the reflux time is within one hour, the fluorescent color of particle is green, prolongs the reflux time, the particle The fluorescent color gradually shifted to red, and after four or five days of reflow, the fluorescence of the microparticles was red, and the particle size of the microparticles increased from 2 nanometers to 4 nanometers during the reflow process. figure 2 and image 3 Given are the absorption and fluorescence spectra of CdTe nanoparticles of different sizes synthesized under the above conditions. Figure 4 It is a fluorescent photo of CdTe nanoparticle aqueous solution with different sizes modified with amine groups on the surface.

[0052] 2. Biocoupling of CdTe nanoparticles:

[0053]

[0054] The produ...

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Abstract

There is a kind of nano particle and micro-sphere biological fluorescence probem and the manufacturing method. The method mainly includes: 1) hydrosulphenyl compound with amidocyanogen is used as stabilizing agent in particle synthesis, water-soluble fluorescence nano particle whose surface is bedecked with amidocyanogen is directly prepared under mild condition, then it takes advantages of the amidocyanogen on the surface of particle to couple with biological system directly, further nano-particle biological fluorescence probe is acquired; 2) said fluorescence nano particle whose surface is bedecked with radical dumpling with different functions is compounded into micro-sphere is inorganic silicon dioxide or organic polymer by various means, fluorescence micro-sphere which can be dispersed equably in aqueous solution is acquired.

Description

technical field [0001] The present invention relates to the synthesis of water-soluble high-efficiency fluorescent and luminescent inorganic semiconductor nanoparticles, the preparation of large-sized microspheres containing fluorescent nanoparticles that can be dispersed in water, the surface biochemical modification of nanoparticles and large-sized microspheres containing fluorescent particles and The application of its fluorescence properties in biological detection, especially the surface biochemical modification of cadmium telluride (CdTe) nanoparticles and large-sized microspheres containing cadmium telluride fluorescent particles and the application of their fluorescence properties in biological detection. Background technique [0002] Due to the quantum size effect, the optical properties of semiconductor particles strongly depend on the size of the particles in the nanometer range. Therefore, nanoparticle materials with different optical properties (such as fluoresce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/08
Inventor 高明远
Owner 高明远
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