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Method of inducing cancer cell death and tumor regression

A technology of cancer and radiotherapy, which is applied in the direction of anti-tumor drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as weak anti-tumor activity

Inactive Publication Date: 2004-03-03
乔治Q 戴利
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While such agents have potential for use as new cancer therapeutics, it is believed that many signaling inhibitors act in a cytostatic rather than cytotoxic manner by blocking cellular progression through the cell cycle
They differ from conventional cancer chemotherapy drugs by being slightly toxic but also having weaker antitumor activity
[0007] Therefore, challenges remain in delivering new and improved cancer treatments

Method used

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  • Method of inducing cancer cell death and tumor regression
  • Method of inducing cancer cell death and tumor regression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and 2

[0108] Embodiment 1 and 2 capsule preparations

Embodiment 1

[0109] Example 1 Example 2 ％ composition mg / capsule mg / capsule composition Solid solution 100 400.0 84.2 Silica NF (1) 0.625 2.5 0.5 Magnesium Stearate NF (2) 0.125 0.5 0.1 Croscarmellose sodium NF 11.000 44.0 9.3 Pluronic F68 NF 6.250 25.0 5.3 Silica NF (3) 0.625 2.5 0.5 Magnesium Stearate NF (4) 0.125 0.5 0.1 Total 118.750 475.00 Capsule Model No.4 No.0 Method (embodiment 1 to 2) Prepare solid solution

[0110] ％ composition g / batch composition FPT inhibitory compound 80 33.3 Povidone NF K29 / 32 160 66.6 Dichloromethane 5000mL evaporate

[0111] The crystalline FPT inhibitory compound and povidone were dissolved in dichloromethane. The solution is dried using a suitable solvent spray dryer. The residue is then processed into fine particles by grinding. Pass the powder through a 30-mesh sieve. X-ray analysis indicated that the resulting powder was amorphous.

[0112] The s...

Embodiment 3 and 4

[0113] Embodiment 3 and 4 capsule preparations

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PUM

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Abstract

Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.

Description

field of invention [0001] The present invention describes new methods of treating individuals with cancer, including neoplastic and metastatic disease. In particular, the present invention provides methods of treating cancer comprising the combined use of (1) a farnesyl protein transferase ("FPT") inhibitor and (2) other Ras signaling pathway inhibitors to induce a synergistic level of cancer cell death ( especially apoptosis), thereby enabling the use of low-dose regimens. Background of the invention [0002] Figure 1 of this specification is a simplified linear depiction of the signal transduction pathways leading to cell proliferation. This pathway is referred to herein as the "Ras signaling pathway" because Ras is the key transmitter in the pathway, receiving signals from upstream elements (eg, growth factor receptors) and transmitting them to downstream elements. [0003] The signaling pathways initiated by growth factor receptors that lead to cell p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K31/473A61K31/495A61K31/505A61K31/506A61K45/06A61P35/00A61P35/02A61P43/00
CPCA61K45/06A61K31/495A61K31/505Y10S514/922A61K31/473Y10S514/908A61P35/00A61P35/02A61P43/00A61K31/435A61K31/445A61K2300/00
Inventor 乔治Q·戴利
Owner 乔治Q 戴利
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