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Artificially recombinant H9N2 hypotype influenza virus and its uses

An influenza virus, H9N2 technology, applied in antiviral agents, viruses/phages, medical preparations containing active ingredients, etc., can solve the problems of short immunization period, high vaccine cost, poor adaptability, etc. The effect of improving the quality of vaccines

Active Publication Date: 2004-11-17
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, due to the poor adaptability of chicken embryos isolated from wild strains, the currently used vaccines have disadvantages such as high cost and short immunity period.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The artificially recombined H9N2 subtype influenza virus is the artificially recombined H9 subtype influenza virus A / Harbin / Re-2 / 2003 (H9N2), which has the same characteristics as the H9N2 subtype avian influenza virus A / chicken / Guangxi / 10 / 99 (H9N2) HA and NA genes and six internal genes PB2, PB1, PA, NP, M and NS of influenza virus A / PR / 8 / 34 (H1N1), the deposit number is CCTCC-V200311.

[0016] The above-mentioned artificially recombined H9N2 subtype influenza virus has extensive cross immunity to H9N2 avian influenza virus prevailing in my country, has high-titer chicken embryo adaptability, and has no pathogenicity to chicken and chicken embryo.

[0017] The application of the aforementioned artificially recombined H9N2 subtype influenza virus in vaccines for preventing and treating animal and human H9N2 subtype influenza.

[0018] The invention is an artificially produced H9N2 subtype recombinant influenza virus A / Harbin / Re-2 / 2003 (strain number Re-2), the virus HA ...

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PUM

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Abstract

The invention relates to an artificial recombination N9 hypotype influenza virus A / Harbin / Re-2 / 2003 (H9N2), artificial recombination H9 hypotype influenza virus A / Harbin / Re-2 / 2003(H9N2) characterized in that, it includes a HA of H9N2 hypotype fowl influenza virus A / chicken / Guangxi / 10 / 99(H9N2) and six internal genes of influenza virus A / PR / 8 / 34(H1N1), PB2, PB1, PA, NP, M and NS. its storage number is CCTCC-V200311.

Description

Technical field: [0001] The invention relates to an artificially recombined H9 subtype influenza virus A / Harbin / Re-2 / 2003 (H9N2) and the application of the virus in vaccines for preventing and treating H9N2 subtype influenza of animals and humans. Background technique: [0002] Avian influenza virus (AIV) is an important pathogen of respiratory diseases in birds and some mammals. AIV belongs to in taxonomy: Virus Kingdom (Vira) - Orthomyxoviridae (Orthomyxoviridae) - Influenza Virus A and B - avian influenza virus (avian influenza virus). [0003] According to the different surface protein antigenicity, avian influenza virus (AIV) is divided into 15 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes. The H9N2 subtype AIV was first introduced in the United States in 1966. It appeared for the first time in the turkey, and it has been widely distributed and popular in wild birds and poultry worldwide in the past 10 years. In 1998, this subtype of virus was isolated from pig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/155A61P31/16C12N7/01
Inventor 陈化兰于康震李雁冰田国彬
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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