Enoxacin Glyconate little volume injection and its preparation method
A technology of enoxacin and enoxacin, which is applied in the field of small-volume injection of enoxacin gluconate and its preparation, can solve the problems of limited clinical application range, insufficient stability, easy oxidation, etc., and achieve definite curative effect , good stability and easy to use
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Embodiment 1
[0014] Enoxacin Gluconate 167.5g
[0015] Water for injection 2000ml
[0016] A total of 1000 injections were made
[0017] Preparation process and preparation of liquid medicine:
[0018] Add 1000ml of water for injection at 50-60°C in the batching pot, then add the prescribed amount of enoxacin gluconate, stir, add 10g of activated carbon for needles after fully dissolved, heat and boil for 15 minutes, filter, and use 0.1N hydrochloric acid for the filtrate After adjusting the pH to 4.0-5.5, add water to the full amount, and the measured content should be 93.0%-107.0% of the marked amount. After passing the test, filter it with a 0.45μm microporous membrane, and hand the filtrate to the potting group;
[0019] Filling and sealing: the ampoules used for filling are washed with water for injection, dried, and the liquid medicine enters the injection filling and sealing machine, filled in the ampoules, and then filled with nitrogen gas to seal.
[0020] Sterilization: Steril...
Embodiment 2
[0055] Enoxacin Gluconate 167.5g
[0056] Glucose 100g
[0057] Water for injection 2000ml
[0058] A total of 1000 pieces were made
[0059] The preparation method is the same as in Example 1 except that the auxiliary materials are added according to the prescription amount.
Embodiment 3
[0061] Enoxacin Gluconate 167.5g
[0062] Sodium chloride 18g
[0063] Water for injection 2000ml
[0064] A total of 1000 pieces were made
[0065] The preparation method is the same as in Example 2 except that the auxiliary materials are added according to the prescription amount.
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