30 results about "Enoxacin" patented technology

A method for preparing gluconate enoxacin comprises the following steps: glucono-delta-lactone is dissolved in water, and enoxacin is dissolved in absolute ethyl alcohol; the obtained two mixtures are added to a there-neck bottle and stirred away from light for reaction; the obtained solution is filtered, then added with the absolute ethyl alcohol, recrystallized at low temperature, filtered, rinsed, and dried in vacuum to obtain a gluconate enoxacin crude product; then the gluconate enoxacin crude product is dissolved, absorbed, filtered, washed and dried into powder injection. The method for preparing the gluconate enoxacin has the advantages of short reaction time, high production efficiency and stable quality.

The invention relates to an enoxacin ophthalmic sustained-release gel and a preparation method thereof, which has the characteristics of maintaining effective drug concentration for a long time and good compatibility. It is composed of the following components: component content (weight%) enoxacin 0.1-1, thickener 0.1-40, preservative 0.001-3, isotonic regulator 0.1-10, pH regulator to adjust the pH value The amount is 4.5-9, the balance of water. It is to dissolve enoxacin in water, add a thickener and let it stand overnight, then add preservatives and isotonic regulators, stir to dissolve, adjust the pH to 4.5-9 with a pH regulator, and pass the solution through a microporous membrane It is prepared by filtering and adding water from the filter to the total amount. This ophthalmic preparation is suitable for treating bacterial conjunctivitis, keratitis and other eye infections.

The invention discloses a preparation method for a molecularly imprinted composite membrane material capable of selectively recognizing and separating enoxacin, and belongs to the technical field of novel materials. The preparation method comprises the following steps: synthesizing polydopamine modified carbon nanotubes according to a dopamine biomimetic principle; on the substrate of polydopaminemodified carbon nanotubes, using enoxacin was as a template molecule, 3-aminopropyltriethoxysilane as a functional monomer and tetraethyl silicate as a cross-linking agent to synthesize an enoxacin molecularly imprinted polymer; and using polyacryloylmorpholine modified polyvinylidene fluoride as a substrate material to prepare the molecularly imprinted composite membrane which has a certain anti-fouling property and is used for detecting residual enoxacin in waste water. The preparation method provided by the invention has the characteristics of simple and convenient operation, easy implementation, high yield rate, mild reaction conditions and the like, and is expected to be applied to industrial production. In addition, static adsorption and selective permeation experiments show that the prepared molecularly imprinted composite film has good separation performance and high selectivity to the enoxacin.

The invention discloses a fluoroquinolones-resistant specific monoclonal antibody hybridoma cell strain, a monoclonal antibody generated based on the cell strain, and the application thereof. The preservation number of the cell strain is CCTCC No.C2015221. The cell strain can stably secrete a monoclonal antibody specific to fluoroquinolones. The result of an indirect ELISA test shows that, the monoclonal antibody is high in sensitivity and strong in universality for the drug detection of ciprofloxacin, enrofloxacin, norfloxacin, pefloxacin, enoxacin and the like. The monoclonal antibody is applied to other immunoassay products, such as the preparation of immunogold labeling cards, immune affinity chromatography gels and the like. Obtained products are still high in sensitivity, high in selectivity, strong in enrichment and strong in universality for target detection. Therefore, the monoclonal antibody can be widely applied to the trace residual qualitative and semi-quantitative analysis of mainly fluoroquinolones in the fields of agriculture, food, environment and the like.