6 results about "Enoxacin" patented technology

The invention belongs to the technical field of veterinary drugs, and discloses a preparation method and application of pH response type enrofloxacin granules for treating porcine respiratory bacterial mixed infection. The invention provides the enrofloxacin coated particle, the enrofloxacin coated particle has pH response capability, is not released in a stomach pH environment and can be quickly released in a near small intestine pH environment, so that the stomach irritation of enrofloxacin is reduced, and the enrofloxacin is ensured to be absorbed at an optimal part. According to the enrofloxacin coated granules, the bitter taste of the medicine is effectively covered, the administration frequency is reduced, and the effective plasma concentration maintaining time is prolonged. Meanwhile, the enrofloxacin coated granules have a good treatment effect on porcine respiratory diseases caused by mixed infection of various bacteria.

The invention discloses an intelligent dynamics modeling method and system for enrofloxacin solution stability prediction, and relates to the technical field of intelligent models. Comprising the following steps: associating influence data in an enrofloxacin solution transportation process according to a time sequence; a delay response factor is introduced, the dynamic relation between the influence data change and the solubility of the enrofloxacin solution is adjusted, the solubility of the enrofloxacin solution is reflected by an Arrhenius reaction kinetic model, and the Arrhenius reaction kinetic model is associated with the delay response factor to generate a time delay kinetic model. According to the method, on the basis of the Arrhenius reaction kinetic model in the prior art, the delay response factor is added, and the time delay kinetic model is constructed, so that the defect of the Arrhenius reaction kinetic model in the aspect of processing the nonlinear lag relationship is overcome; the stability of the solubility of the enrofloxacin solution can be predicted in the transportation and storage process of the enrofloxacin solution.

The present application belongs to the field of chemical synthesis and pesticides, and particularly relates to a preparation method of an enoxacin intermediate 5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-ketone. The present application comprises: using 3-ethylthiobutyraldehyde and methyl acetoacetate as raw materials, generating 2-acetyl-5-(ethylthio)hex-2-enate acid methyl ester through a Brain-Von Eggers reaction, then performing Michael addition and Claisen ester condensation with dimethyl malonate, and then performing hydrolysis through sodium hydroxide, and heating decarboxylation through hydrochloric acid to obtain 5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-ketone. The preparation method is simple, convenient to operate, and easy to be scaled up in industry, and finally, the total yield of the similar one-pot reaction is as high as 77%.

The invention belongs to the technical field of nano material detection, and particularly discloses a double-ligand lanthanide series metal organic framework Tb-MOF for rapidly detecting enoxacin and a rapid detection method for enoxacin concentration. According to the invention, 2, 6-pyridinedicarboxylic acid and 2-aminoterephthalic acid are used as modification ligands to construct Tb-MOF, and after enoxacin is added into a system of the Tb-MOF, the fluorescence intensity and fluorescence color of the Tb-MOF are subjected to characteristic change due to an antenna effect, so that the fluorescence colorimetric sensor is constructed. A portable detection device based on a smart phone is further designed, a cloud server data analysis system integrated with a machine learning algorithm is fused with the smart phone, and collection, correction, analysis and result display of fluorescence color data can be efficiently completed. According to the invention, the capturing and processing capability of a modern smart phone on fluorescence color signals is fully utilized, and a set of solution which is convenient to operate and user-friendly is provided for on-site detection of enoxacin.

A combination therapy comprising enoxacin, palbociclib, and fulvestrant is provided, along with a method for treating locally advanced or metastatic breast cancer with PIC3CA mutations, hormone receptor-positive (HR+), and HER2-negative (HER2-), the method comprising administering therapeutically effective amounts of enoxacin, palbociclib, and fulvestrant. The combination therapy produced statistically significant and clinically meaningful improvements in comparable patients compared to administration of palbociclib and fulvestrant alone.

The invention discloses a jackfruit nucleus carbon quantum dot fluorescent probe, a preparation method thereof and an application of the jackfruit nucleus carbon quantum dot fluorescent probe in rapid detection of enoxacin. Green and environment-friendly waste jackfruit nucleus is selected as a carbon source, and JNW CDs with good luminescence stability and high solubility are synthesized through a one-step hydrothermal method after citric acid hydrolysis modification; the method is used for rapidly detecting the content of enoxacin in an actual sample, resource recycling can be achieved while the residual level of enoxacin in food is monitored, and environmental pollution is reduced.