30 results about "Enoxacin" patented technology

The invention discloses bis-fluoroquinolone thiadiazole urea N-methyl enoxacin derivatives as well as a preparation method and an application thereof. The general chemical structure formula of the derivatives is shown in the formula I as follows in the description. In the formula I, R is ethyl, cyclopropyl, fluoroethyl, an oxazine ring consisting of C-8 or a thiazine ring consisting of C-8; L is an independent Cl or F atom, 1-piperazinyl or substituted piperazine-1-yl or a nitrogen fused heterocyclic ring; X is CH, N or F-substituted C atom (F-C) or a methoxy substituted C atom (CH3O-C). The bis-fluoroquinolone thiadiazole urea N-methyl enoxacin derivatives realize organic combination of a bis-fluoroquinolone skeleton and the thiadiazole heterocyclic ring with functional urea pharmacophores, so that transition and superposition of different pharmacophores are realized, anti-tumor activity and selectivity of fluoroquinolone are increased, toxic and side effects on normal cells are reduced, and the derivatives can be taken as an anti-tumor active substance for developing anti-tumor drugs with novel structures.

The present invention relates to new Enoxacin gluconate preparation, and is especially small dosage Enoxacin gluconate injection and its preparation process. The injection consists of Enoxacin gluconate as active component pharmacologically acceptable carrier component. The injection of the present invention has stability superior to that of great dosage Enoxacin gluconate injection, and the active component may be also prepared into powder for injection and eye drop.