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Anti-oxidization oxytetracycline hydrochloride injection and preparation method thereof

Oxytetracycline hydrochloride and anti-oxidation technology, applied in the field of new medicine, can solve problems such as poor quality controllability, unstable products, easy oxidation and blackening, etc., and achieve high production efficiency, maintain drug efficacy, and significant curative effect

Inactive Publication Date: 2018-10-12
安徽天安生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many long-acting oxytetracycline injection manufacturers in China, but the products produced by most pharmaceutical companies are extremely unstable, easy to oxidize and turn black, and have poor quality controllability

Method used

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  • Anti-oxidization oxytetracycline hydrochloride injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] An anti-oxidation oxytetracycline hydrochloride injection, which is composed of the following raw materials in parts by weight: 35 parts of anti-oxidation oxytetracycline hydrochloride, 12 parts of methoxquinic acid, 10 parts of enoxacin, 6 parts of acetaminophen, Dandelion-Isatis root extract 22 parts, glucose 6 parts, sodium chloride 5 parts, calcium chloride 2 parts, zinc sulfate 3 parts, ethanol 80 parts, triethanolamine 16 parts, vitamin C 13 parts, purified water 180 parts.

[0034] The preparation method of described antioxidant oxytetracycline hydrochloride injection comprises the following steps:

[0035] (1) dissolving methoxyquinoic acid, enoxacin, acetaminophen and triethanolamine in ethanol to obtain an alcoholic solution;

[0036] (2) Heat the purified water to 35°C, slowly add the antioxidant oxytetracycline hydrochloride into the biochemical water, stir while adding, add glucose after the dissolution is complete, add dandelion-isatidis extract, vitamin C...

Embodiment 2

[0039] An anti-oxidation oxytetracycline hydrochloride injection, which is composed of the following raw materials in parts by weight: 55 parts of anti-oxidation oxytetracycline hydrochloride, 15 parts of methoxquinic acid, 15 parts of enoxacin, 7 parts of acetaminophen, Dandelion-isatis root extract 26 parts, glucose 8 parts, sodium chloride 8 parts, calcium chloride 4 parts, zinc sulfate 5 parts, ethanol 100 parts, triethanolamine 20 parts, vitamin C 16 parts, purified water 240 parts.

[0040] The preparation method of described antioxidant oxytetracycline hydrochloride is:

[0041] (1) Add oxytetracycline and antioxidant polypeptide to purified water at 25°C, stir at 120r / min for 30min, add hydrochloric acid after stirring, put the mixture in a reaction kettle and react at 30°C for 3h;

[0042] (2) Cool the mixed solution after the above reaction to 20°C, add methanol to the mixed solution, and ultrasonicate for 25 minutes at a power of 120W. The crystals of oxytetracycli...

Embodiment 3

[0046]An anti-oxidation oxytetracycline hydrochloride injection, which is composed of the following raw materials in parts by weight: 45 parts of anti-oxidation oxytetracycline hydrochloride, 13 parts of methoxquinic acid, 12 parts of enoxacin, 6 parts of acetaminophen, Dandelion-isatis root extract 23 parts, glucose 7 parts, sodium chloride 6 parts, calcium chloride 3 parts, zinc sulfate 4 parts, ethanol 85 parts, triethanolamine 17 parts, vitamin C 14 parts, purified water 200 parts.

[0047] The preparation method of described antioxidant oxytetracycline hydrochloride is:

[0048] (1) Add oxytetracycline and antioxidant polypeptide to purified water at 28°C, stir at 150r / min for 40min, add hydrochloric acid after stirring, put the mixture in a reaction kettle and react at 35°C for 4h;

[0049] (2) Cool the mixed solution after the above reaction to 25°C, add methanol to the mixed solution, and ultrasonicate for 30 minutes at a power of 120W. The crystals of oxytetracycline...

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Abstract

The invention discloses anti-oxidization oxytetracycline hydrochloride injection and a preparation method thereof and relates to the technical field of medicines. The anti-oxidization oxytetracyclinehydrochloride injection is prepared from the following raw materials in parts by weight: 35 to 55 parts of anti-oxidization oxytetracycline hydrochloride, 12 to 15 parts of miloxacin, 10 to 15 parts of enoxacin, 6 to 7 parts of p-acetamidophenol, 22 to 26 parts of herba taraxaci-radix isatidis extracting solution, 6 to 8 parts of glucose, 5 to 8 parts of sodium chloride, 2 to 4 parts of calcium chloride, 3 to 5 parts of zinc sulfate, 80 to 100 parts of ethanol, 16 to 20 parts of triethanolamine, 13 to 16 parts of vitamin C and 180 to 240 parts of purified water; the anti-oxidization oxytetracycline hydrochloride is prepared through a specific method and is matched with other raw materials to use, so that the prepared injection has antibacterial, sterilization and inflammation-diminishing effects; meanwhile, the injection has stable properties and is not easily oxidized and the medicinal effect can be kept for a long period; the injection also can provide necessary nutrients for life bodies, is applicable to disease prevention and bacterium resistance of domestic fowl, domestic animals and large-size animals and has a remarkable curative effect.

Description

Technical field: [0001] The invention relates to the technical field of new medicines, in particular to an anti-oxidation oxytetracycline hydrochloride injection and a preparation method thereof. Background technique: [0002] Oxytetracycline is a light yellow tablet or sugar-coated tablet, belonging to the tetracycline class, which can be used to treat rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever, infections of the genus Mycoplasma and chlamydia infections. [0003] Oxytetracycline has a broad-spectrum anti-pathogenic microorganism effect, is a rapid bacteriostatic agent, and has a bactericidal effect on some bacteria at high concentrations. Its mechanism of action is that the drug can specifically bind to the A position of the ribosomal 30S subunit, preventing the connection of aminoacyl-tRNA at this position, thereby inhibiting the growth of the peptide chain and affecting the protein synthesis of bacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/288A61K36/315A61K31/65A61K9/08A61K47/42A61P31/04A61P29/00A61K31/167A61K31/4741A61K31/496
CPCA61K9/0019A61K9/08A61K31/167A61K31/4741A61K31/496A61K31/65A61K36/195A61K36/288A61K36/315A61K47/42A61P29/00A61P31/04A61K2300/00Y02A40/70
Inventor 程贤防
Owner 安徽天安生物科技股份有限公司
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