Preparation method of molecularly imprinted composite membrane material for selective recognition and separation of enoxacin

A technology of enoxacin and molecular imprinting, applied in semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve problems such as environmental biological and ecological impact, adverse impact on human health and survival, etc. More spots, fast adsorption kinetics, improved hydrophilicity

Active Publication Date: 2020-06-09
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since enoxacin cannot be completely absorbed by the human body or animals, a large part of it is excreted into the environment with feces and urine in the form of original or metabolites. Ecological impacts that may ultimately adversely affect human health and survival

Method used

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  • Preparation method of molecularly imprinted composite membrane material for selective recognition and separation of enoxacin

Examples

Experimental program
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Effect test

Embodiment 1

[0045] (1) Synthesis of polydopamine-modified multi-walled carbon nanotubes

[0046] Polydopamine-modified multi-walled carbon nanotubes were synthesized based on the biomimetic principle of dopamine. Disperse dopamine in the tris buffer solution, adjust the pH until it dissolves and changes color, put the multi-walled carbon nanotubes into the mixed solution, stir at room temperature for 3 hours, and fully react, so that the polydopamine layer is evenly wrapped in the polydopamine layer. nanotube surface. After the reaction, the obtained product was centrifuged, washed several times with deionized water to remove unreacted substances, and dried in vacuum for use.

[0047] (2) Preparation of enoxacin molecularly imprinted polymer

[0048] First, disperse 0.3mmol of enoxacin and 0.2ml of 3-aminopropyltriethoxysilane (APTES) in 30ml of ethanol solution and stir for 30 minutes; add a certain amount of tetraethyl silicate (TEOS) Continue stirring for 15 minutes; add ammonia wat...

Embodiment 2

[0061] (1) Synthesis of polydopamine-modified multi-walled carbon nanotubes

[0062] Polydopamine-modified multi-walled carbon nanotubes were synthesized based on the biomimetic principle of dopamine. Disperse dopamine in the tris buffer solution, adjust the pH until it dissolves and changes color, put the multi-walled carbon nanotubes into the mixed solution, stir at room temperature for 12 hours, and fully react, so that the polydopamine layer is evenly wrapped in the polydopamine layer. nanotube surface. After the reaction, the obtained product was centrifuged, washed several times with deionized water to remove unreacted substances, and dried in vacuum for use.

[0063] (2) Preparation of enoxacin molecularly imprinted polymer

[0064] First, disperse 0.5mmol of enoxacin and 0.2ml of 3-aminopropyltriethoxysilane (APTES) in 30ml of ethanol solution and stir for 30 minutes; add a certain amount of tetraethyl silicate (TEOS) Continue stirring for 15 minutes; add ammonia wa...

Embodiment 3

[0077] (1) Synthesis of polydopamine-modified multi-walled carbon nanotubes

[0078] Polydopamine-modified multi-walled carbon nanotubes were synthesized based on the biomimetic principle of dopamine. Disperse dopamine in the tris buffer solution, adjust the pH until it dissolves and changes color, put the multi-walled carbon nanotubes into the mixed solution, stir at room temperature for 8 hours, and fully react, so that the polydopamine layer is evenly wrapped in the polydopamine layer. nanotube surface. After the reaction, the obtained product was centrifuged, washed several times with deionized water to remove unreacted substances, and dried in vacuum for use.

[0079] (2) Preparation of enoxacin molecularly imprinted polymer

[0080] First, disperse 0.4mmol of enoxacin and 0.2ml of 3-aminopropyltriethoxysilane (APTES) in 30ml of ethanol solution and stir for 30 minutes; add a certain amount of tetraethyl silicate (TEOS) Continue to stir for 15 minutes; add ammonia wate...

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Abstract

The invention discloses a preparation method for a molecularly imprinted composite membrane material capable of selectively recognizing and separating enoxacin, and belongs to the technical field of novel materials. The preparation method comprises the following steps: synthesizing polydopamine modified carbon nanotubes according to a dopamine biomimetic principle; on the substrate of polydopaminemodified carbon nanotubes, using enoxacin was as a template molecule, 3-aminopropyltriethoxysilane as a functional monomer and tetraethyl silicate as a cross-linking agent to synthesize an enoxacin molecularly imprinted polymer; and using polyacryloylmorpholine modified polyvinylidene fluoride as a substrate material to prepare the molecularly imprinted composite membrane which has a certain anti-fouling property and is used for detecting residual enoxacin in waste water. The preparation method provided by the invention has the characteristics of simple and convenient operation, easy implementation, high yield rate, mild reaction conditions and the like, and is expected to be applied to industrial production. In addition, static adsorption and selective permeation experiments show that the prepared molecularly imprinted composite film has good separation performance and high selectivity to the enoxacin.

Description

technical field [0001] The invention relates to the preparation and application of a high-performance enoxacin molecularly imprinted composite membrane, which belongs to the technical field of new materials. Background technique [0002] Membrane separation technology (MST) has been widely used in the fields of medicine, energy, and wastewater treatment due to its advantages of high efficiency, energy saving, and environmental protection, and has attracted great interest from scientists and engineers in the fields of materials science, biochemistry, and chemical engineering. . However, traditional membrane separation cannot perform a single, efficient and selective separation of a certain substance, nor can it simultaneously achieve effective separation of molecular and ionic impurities. Molecular imprinting technology (MIT) is that when template molecules (imprinted molecules) are in contact with polymer monomers, multiple action sites will be formed, and specific recognit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D69/12B01D71/34B01D67/00B01J20/26B01J20/28B01J20/30C08F8/30C08F14/22C08K9/04C08K7/24
CPCB01D67/0011B01D67/0013B01D69/12B01D71/34B01J20/20B01J20/261B01J20/262B01J20/28033B01J2220/46B01J2220/4806B01J2220/4812C08F8/30C08K7/24C08K9/08C08F14/22
Inventor 高佳卢健杨丽丽闫永胜
Owner JIANGSU UNIV
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