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Preparation method of molecularly imprinted composite membrane material for selective separation of enoxacin

A technology of molecular imprinting and enoxacin, which is applied in semipermeable membrane separation, chemical instruments and methods, membranes, etc., can solve the problems of low flux, low separation performance and selectivity, hydrophilicity and antifouling of molecular imprinted membranes Poor performance and other problems, to achieve the effect of more recognition sites, significant separation effect, and improved hydrophilicity

Inactive Publication Date: 2018-06-26
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the defects of the prior art such as low separation performance and selectivity, and solve the defects of low flux, poor hydrophilicity and anti-fouling performance of traditional molecularly imprinted membranes. The separation efficiency of the molecule (enoxacin) was greatly improved

Method used

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  • Preparation method of molecularly imprinted composite membrane material for selective separation of enoxacin
  • Preparation method of molecularly imprinted composite membrane material for selective separation of enoxacin

Examples

Experimental program
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Effect test

Embodiment 1

[0044] S1. Preparation of carbon nanosphere (CNS) gel

[0045] After mixing phloroglucinol: terephthalaldehyde: deionized water with a ratio of 0.063g: 0.05g: 28mL, ultrasonic treatment to fully dissolve it, and mechanical stirring at 70°C for 30min to form a carbon nanosphere gel ; The resulting CNS gel is 4g / L, diluted with water to 50, 100, 200, 400 and 800mg / L for later use, for the subsequent film-making process, as a coagulation bath required during phase inversion.

[0046] S2. Preparation of carbon nanosphere grafted polyvinylidene fluoride film (CNS@PVDF)

[0047] First, put polyvinylidene fluoride powder: polyvinylpyrrolidone: N-methylpyrrolidone (NMP) with a ratio of 4g: 0.1g: 20mL into the flask and seal it, and keep stirring mechanically in a water bath at 60°C for 24 hours to form Uniform casting solution. Afterwards, vacuumize to remove the air bubbles in the casting solution. Then the casting solution was poured on the glass plate, and the film was scraped, ...

Embodiment 2

[0060] S1. Preparation of carbon nanosphere (CNS) gel

[0061] After mixing phloroglucinol: terephthalaldehyde: deionized water with a ratio of 0.063g: 0.05g: 28mL, ultrasonic treatment to fully dissolve it, and mechanical stirring at 70°C for 30min to form a carbon nanosphere gel ; The resulting CNS gel is 4g / L, diluted with water to 50, 100, 200, 400 and 800mg / L for later use, for the subsequent film-making process, as a coagulation bath required during phase inversion.

[0062] S2. Preparation of CNS@PVDF

[0063] First, put polyvinylidene fluoride powder: polyvinylpyrrolidone: N-methylpyrrolidone (NMP) with a ratio of 4g: 0.3g: 20mL into the flask and seal it, and keep stirring mechanically in a water bath at 60°C for 24 hours to form Uniform casting solution. Afterwards, vacuumize to remove the air bubbles in the casting solution. Then the casting solution was poured on the glass plate, and the film was scraped, and the glass plate covered with the casting solution was...

Embodiment 3

[0076] S1. Preparation of carbon nanosphere (CNS) gel

[0077] After mixing phloroglucinol: terephthalaldehyde: deionized water with a ratio of 0.063g: 0.05g: 28mL, ultrasonic treatment to fully dissolve it, and mechanical stirring at 70°C for 30min to form a carbon nanosphere gel ; The resulting CNS gel is 4g / L, diluted with water to 50, 100, 200, 400 and 800mg / L for later use, for the subsequent film-making process, as a coagulation bath required during phase inversion.

[0078] S2. Preparation of CNS@PVDF

[0079] First, put polyvinylidene fluoride powder: polyvinylpyrrolidone: N-methylpyrrolidone (NMP) with a ratio of 4g: 0.5g: 20mL into the flask and seal it, and keep stirring mechanically in a water bath at 60°C for 24 hours to form Uniform casting solution. Afterwards, vacuumize to remove the air bubbles in the casting solution. Then the casting solution was poured on the glass plate, and the film was scraped, and the glass plate covered with the casting solution was...

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Abstract

The invention relates to a preparation method of a molecularly imprinted composite membrane material, and belongs to the technical field of new materials. The specific steps are as follows: firstly, preparing carbon nanosphere gels with different concentrations as a coagulation bath, putting a preparation desired polyvinylidene fluoride membrane into the carbon nanosphere coagulation bath, and preparing a CNS@PVDF membrane through a phase inversion process; secondly, synthesizing a layer of polydopamine on the surface of the CNS@PVDF membrane to obtain a dCNS@PVDF membrane, and grafting doublebonds on the surface of the membrane through a silane coupling agent to facilitate imprinting polymerization reaction; and finally, performing imprinting polymerization reaction by using ethylene glycol dimethacrylate as a cross-linking agent, acrylamide as a functional monomer and azobisisobutyronitrile as an initiator, so that a high-performance imprinted composite membrane for separating enoxacin molecules is prepared based on molecular imprinting technology. The preparation method has the advantages of simple operation, easy implementation and higher yield, and is expected to be applied to industrial production.

Description

technical field [0001] The invention relates to a preparation method and application of a molecularly imprinted composite membrane material for selective separation of enoxacin, belonging to the technical field of new materials. Background technique [0002] Enoxacin, as the third-generation fluoroquinolone antibiotics, has broad-spectrum, strong bactericidal effect, and is still highly sensitive to multidrug-resistant Enterobacteriaceae. It is widely used in the treatment of various bacterial infectious diseases. However, most of enoxacin cannot be completely metabolized by humans and animals, nor can it be completely absorbed by humans or animals, and a large part will be excreted into the environment in the form of original or metabolites with feces and urine, which enter the environment The pharmaceutical ingredients used as environmental foreign aid compounds will have adverse effects on human beings and ecology. The existing methods for separating similar drug compone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/34B01D67/00B01D69/12C08J7/16C08J7/12C08L27/16C08L9/06C08K7/18C02F1/28C02F101/36C02F101/34
CPCB01D67/0079B01D69/12B01D71/34B01D2325/24B01D2325/36C02F1/288C02F2101/34C02F2101/36C08J7/12C08J7/16C08J2327/16C08J2439/06C08K7/18
Inventor 高佳卢健杨丽丽闫永胜
Owner JIANGSU UNIV
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