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Preparation method of molecular engram silicon oxide nanometer particle with sensing molecule identification to TNT

A molecular recognition and nanoparticle technology, applied in the field of material science, can solve the problem that molecular recognition has not been reported, and achieve the effect of easy grafting of organic functional groups, large surface area, and wide range of applications

Inactive Publication Date: 2008-11-05
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as an extension of the core-shell sphere and theoretically better for imprinting, the molecular recognition of composite silica nanoparticles has not been reported yet.

Method used

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  • Preparation method of molecular engram silicon oxide nanometer particle with sensing molecule identification to TNT
  • Preparation method of molecular engram silicon oxide nanometer particle with sensing molecule identification to TNT
  • Preparation method of molecular engram silicon oxide nanometer particle with sensing molecule identification to TNT

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preparation example Construction

[0039] A chemical preparation method for molecularly imprinted silica nanoparticles with sensitive molecular recognition for TNT, comprising using silica spherical particles as a template and modifying the surface with aminopropyl groups, characterized in that: the silica spherical particles are then Further amidation to make its surface with specific functional groups, the preparation process of the present invention comprises the following two steps:

[0040] The first step is to dissolve the functional monomer, the recognized molecule and the cross-linking agent in 50 ml of acetonitrile so that the concentrations are 0.0020-0.0046 mol / L, 0.00264 mol / L and 0.0080-0.0184 mol / L, and then add mass Initiator with a fraction of 2-5% and 20 mg of a two-step modified spherical template, sealed with nitrogen and deoxygenated, heated to 50°C for 6 hours to form oligomers on the surface of the spherical template, and then heated to 60°C React for 18 hours to form a low-degree polymeri...

Embodiment

[0044] Embodiment: According to the precipitation polymerization reaction, using nano-silicon oxide as a template, a two-step reaction can be used to obtain nanocomposite balls.

[0045] 1. Synthesis of monodisperse silica sol nanospheres: at room temperature, dissolve 3.6ml tetraethyl orthosilicate (TEOS) in 88.1ml ethanol and stir for three minutes, then add 11.9ml ammonia water (25%) to the above-mentioned The reaction mixture was stirred vigorously for three minutes, then gently for 24 hours. The obtained silica sol nanospheres were dispersed in toluene after three centrifugation washes.

[0046] (1) The silica nanoparticles obtained above were dispersed in 50 ml of toluene, then 1 ml of aminopropyltriethoxysilane (APTS) was added dropwise, and refluxed for 24 hours under an inert atmosphere. The resulting product was dispersed in toluene after three centrifugal washes.

[0047] (2) Add 0.2 g of anhydrous potassium carbonate to the above-mentioned modified silicon oxide ...

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Abstract

This invention relates to a chemical preparation method of molecular imprinting silicon oxide nanometer particle that possesses sensitive molecular recognition for TNT. It includes: use silicon oxide globular particle as template, modify ammonia propyl on its surface, amidate silicon oxide globular particle, and make its surface taking specified functional group. Preparation of this invention includes following two steps: low-grade polymerize reacting metamer at invariable reaction condition, form oligomer, form coating on template surface, change reaction condition, polymerize coating of template surface, form cross linking outer shell. Ripen coating of globular template surface in cross linking polymerization process, form high cross linking polymer nanometer outer shell, make nanometer outer shell with strong rigidity, large specific surface area, stable spatial structure of forming site, many sites, and good selectivity, and form controllable thick shell nucleocapsid nanometer compound ball taking molecular recognition function.

Description

[0001] Field of the Invention The present invention relates to the field of material science, in particular to a chemical preparation method of molecularly imprinted silicon oxide nanoparticles with sensitive molecular recognition of TNT. Background technique [0002] Silicon oxide composite nanospheres have a wide range of applications in many fields due to their superior characteristics. For example, in the fields of medicine and biology: silica composite nanospheres can be used as a drug delivery system to effectively deliver relief drugs to the lesion or achieve controlled release of drugs; silica composite nanospheres can also be used for biological macromolecules, Such as microencapsulation, migration and release of proteins, enzymes and nucleic acids, gene therapy and disease diagnosis. In the field of material science: Since the core of composite nanospheres is silica nanoparticles, it can be used as a filler for polymer composites to effectively improve the strength a...

Claims

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Application Information

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IPC IPC(8): C01B33/18G01N31/00
Inventor 张忠平高大明
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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