Enoxacin ocular sustained release gelata and preparation thereof

Abstract

The invention relates to an enoxacin ophthalmic sustained-release gel and a preparation method thereof, which has the characteristics of maintaining effective drug concentration for a long time and good compatibility. It is composed of the following components: component content (weight%) enoxacin 0.1-1, thickener 0.1-40, preservative 0.001-3, isotonic regulator 0.1-10, pH regulator to adjust the pH value The amount is 4.5-9, the balance of water. It is to dissolve enoxacin in water, add a thickener and let it stand overnight, then add preservatives and isotonic regulators, stir to dissolve, adjust the pH to 4.5-9 with a pH regulator, and pass the solution through a microporous membrane It is prepared by filtering and adding water from the filter to the total amount. This ophthalmic preparation is suitable for treating bacterial conjunctivitis, keratitis and other eye infections.

Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to an enoxacin ophthalmic sustained-release gel and a preparation method thereof. Background technique:

[0002] According to statistics, more than 80% of the patients who go to see a doctor in ophthalmology are ocular infections. Ophthalmic infections include conjunctivitis, keratitis, and global inflammation; divided from pathogenic bacteria, including bacterial infections and fungal infections. Anti-infective drugs can be used for bacterial infection, but due to the existence of the blood-ocular barrier, the drugs cannot fully penetrate into the eye, and the drug concentration in the intraocular tissue is low. Therefore, the anti-infective drugs used in ophthalmology are those with good permeability, such as tobramycin, cleomycin and chloramphenicol. In recent years, the application of quinolones in ophthalmology has grown rapidly, such as ofloxacin, levofloxacin, norfloxacin...