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Pharmaceutical use of dihydro myricetin

A technology of dihydromyricetin and medicine, which is applied in the application field of dihydromyricetin in the preparation of medicines, and can solve the problems of not disclosing dihydromyricetin and the like

Inactive Publication Date: 2005-05-04
湖南恒生制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] No. 99119123.4 patent has disclosed the method for extracting dihydromyricetin from grape plants, but this patent does not disclose the method for preparing dihydromyricetin by low-temperature treatment and recrystallization; other documents disclose that dihydromyricetin has hypoglycemic effect (see Qin Jieping, Traditional Chinese Medicine and Natural Medicine 2001; 18(5): 351), liver protection (see Zhong Zhengxian, Zhou Guifen, Chen Xuefen, etc. China Science and Technology of Traditional Chinese Medicine 2002; 9(3): 155) and calcium antagonism (see Zhou Xuexian, Zhou Tianda, Tan Chunsheng .Modern Applied Pharmacy 1997; 14(2):8) role; no patent or literature discloses that dihydromyricetin is prepared as a drug for the treatment of oral ulcers, gastric ulcers, duodenal ulcers, acute or chronic pharyngitis, pelvic inflammatory disease and / or Adnexitis, chronic gastritis and / or enteritis

Method used

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  • Pharmaceutical use of dihydro myricetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of dihydromyricetin from Grape dentata

[0020] Take 10kg of dried tender stems and leaves of Snake-toothed Grape, add 100kg of water, soak in warm for 0.5-1 hour, and press-filter; Density 1.05-1.08 (60-70°C thermal measurement), place below 4°C for 24 hours, filter with suction, collect the solid part, dry and finely grind to obtain 1.6kg of crude total flavonoids;

[0021] Get 1.5kg of crude total flavonoids, add 15000ml 95% ethanol, 300g gac, heat and reflux for 0.5 hour, filter with suction, recover ethanol from the filtrate, concentrate under reduced pressure to about 3500ml, leave it at room temperature, after crystallization, filter with suction, dry to obtain crude Crystal 1.18kg;

[0022] Take 1.0kg of crude crystals, add 10000ml of 95% ethanol and 200g of activated carbon, heat and reflux for 0.5 hours, filter with suction, recover ethanol from the filtrate, concentrate under reduced pressure to about 2500ml, and place it at room tempe...

Embodiment 2

[0024] Embodiment 2: the effect of dihydromyricetin on rabbit immune oral ulcer

[0025] Take 30 rabbits, weighing 1.77±0.15kg, both male and female, stratified by gender and weight, and randomly divided into 3 groups. Hair removal on both sides of the back and spine, alcohol disinfection, 20 points are taken from each animal at the hair removal place, and the first group is injected Freund's adjuvant, the other two groups were injected with immune adjuvant, 0.05ml per point, once every 2 weeks, 5 times in total. On the 7th day after the fifth immunization injection, oral administration was given. The first and second groups were given distilled water, and the third group was given 250 mg / kg of dihydromyricetin, with a volume of 2.0 ml / kg, given 4 times a day. , at an interval of 3 hours, for a total of 4 days of administration. During the test period, the oral mucosal ulcers of the animals were observed every day; on the second day after the last administration, blood was co...

Embodiment 3

[0042] Example 3: The effect of dihydromyricetin on oral ulcers caused by Staphylococcus epidermidis in rabbits

[0043] Take 20 New Zealand rabbits, weighing 1.83±0.17kg, both male and female, and divide them into 2 groups randomly according to weight stratification, and inject 1.5 billion CFU / ml of Staphylococcus epidermidis into the buccal mucosa of the New Zealand rabbits at 0.03ml / only After 24 hours, abscesses formed and ruptured into ulcers on their own. From the beginning of ulcer formation, the two groups were given distilled water 2.0ml / kg, dihydromyricetin 250mg / kg, oral administration, the volume was 2.0ml / kg, 4 times a day, with an interval of 3 hours, a total of 3 sky. Before administration and on the 3rd day after administration, the ulcer diameter and the size of the blush around the ulcer were measured with a divider to judge the inflammatory index; from the 3rd day, observations were made twice a day with an interval of 12 hours, and the ulcer healing time w...

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Abstract

The present invention discloses application of dihydromyricetin in preparation of medicine for curing the diseases of stomatocace, gastric ulcer, duodenal ulcer, acute or chronic pharyngitis, pelvic inflammation and / or annexitis, chronic gastritis and / or enteritis. It can be mixed with pharmaceutically acceptable carrier, and the prepared medicine can contain dihydromyricetin only, also can be composition containing dihydromyricetin, and said prepared medicine can be tablet, capsule, granula preparation or injection preparation, and every tablet or every capsule or every bag of granules or every injection contains 50-1000 mg of dihydromyricetin. Said invention also relates to a method for preparing dihydromyricetin from ampelopsis grossedentata by adopting low-temperature treatment recrystallization process.

Description

technical field [0001] The invention relates to the application of dihydromyricetin in the preparation of medicines, specifically for the preparation and treatment of oral ulcer, gastric ulcer, duodenal ulcer, acute or chronic pharyngitis, pelvic inflammatory disease and / or adnexitis, chronic gastritis and / or enteritis medicine. At the same time, it relates to a method for preparing dihydromyricetin from Eperodonta grape. Background technique [0002] No. 99119123.4 patent has disclosed the method for extracting dihydromyricetin from grape plants, but this patent does not disclose the method for preparing dihydromyricetin by low-temperature treatment and recrystallization; other documents disclose that dihydromyricetin has hypoglycemic effect (see Qin Jieping, Traditional Chinese Medicine and Natural Medicine 2001; 18(5): 351), liver protection (see Zhong Zhengxian, Zhou Guifen, Chen Xuefen, etc. China Science and Technology of Traditional Chinese Medicine 2002; 9(3): 155) ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K31/353A61P1/02A61P1/04A61P11/04A61P15/00
Inventor 陈立峰蔡光先王实强
Owner 湖南恒生制药股份有限公司
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