Antibiotic compositions for treatment of the eye, ear and nose
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A composition, hydration technology, application in ear and nose infection, treatment of eye field, can solve the problem of limited efficacy, anti-oral antibiotics and the risk of pathogen resistance etc.
Inactive Publication Date: 2005-08-10
ALCON LAB INC
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Problems solved by technology
Use of oral antibiotics for ear infections in young children has limited efficacy and poses serious risk of pathogen resistance to oral antibiotics
Method used
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Embodiment 1
[0065] Eye / Ear / Nose Solution
[0066] components Amount (wt%)
[0067] Mofloxacin 0.35
[0068] Sodium acetate 0.03
[0069] Acetic acid 0.04
[0070] Mannitol 4.60
[0071] EDTA0.05
[0072] Benzalkonium chloride 0.006
[0073] Appropriate amount of water, up to 100
Embodiment 2
[0075] Eye / Ear / Nasal Suspension
[0076] components Amount (wt%)
[0077] Mofloxacin 0.3
[0078] Dexamethasone, micronized 0.10
[0079] USP
[0080] Benzalkonium Chloride 0.01
[0081] Disodium edetate, 0.01
[0082] USP
[0083] Sodium Chloride, USP 0.3
[0084] Sodium sulfate, USP 1.2
[0085] Tyloxapor, USP 0.05
[0086] Hydroxyethylcellulose 0.25
[0087] Sulfate and / or Hydroxide qs for pH adjustment
[0088] Sodium, NF round to 5.5
[0089] Pure water, USP qs, to 100
Embodiment 3
[0091] eye ointment
[0092] components Amount (wt%)
[0093] Mofloxacin 0.35
[0094] Mineral Oil, USP 2.0
[0095] White petrolatum, USP QS, to 100
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Abstract
Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.
Description
[0001] This application is a divisional application filed on September 29, 1999, application number 99811509.6, and titled "Antibiotic Composition for Treating Eyes, Ears and Nose". technical field [0002] The present invention relates to topical antibiotic pharmaceutical compositions for the treatment of eye, ear and nose infections, particularly bacterial infections, and methods of treating eye, ear and nose infections by applying these compositions to said affected tissues. The compositions and methods of the present invention are based on the use of a new class of antibiotics. Compositions of the present invention may also contain one or more anti-inflammatory agents. Background technique [0003] The use of quinolone antibiotics to treat infections represents the current state of the art in the field of ophthalmic compositions and methods of treatment. For example, an ophthalmic composition containing the quinolone ciprofloxacin is marketed by the company Alcon Labora...
Claims
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Application Information
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