Adenosme generation bacteria and method for generating adenosine by fermentation

A technology for producing bacteria and adenosine, which is applied in the direction of fermentation and bacteria, and can solve the problems of limited production and high production cost of adenosine
CN1657608AInactive Publication Date: 2005-08-24江苏省苏微微生物研究有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
江苏省苏微微生物研究有限公司
Publication Date
2005-08-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

An adenosine generating bacterium Bacillus subtilis JSIM-1025 is disclosed. A fermenting method for generating adenosine with high output (more than 23g / L) features that the fermentation is conducted at 37 deg.C for 60 hr in such conditions that the optional concentration of the ferment cream as the optical component of culture medium is 1.8%, the optimal pH value is 6.5, and the optimal oxygen solubility is 40%.
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Description

technical field

[0001] The present invention relates to a novel microbial strain and a fermentation method for producing its metabolites using the strain. Specifically, the present invention relates to a high-yield adenosine-producing bacterium, and also relates to a fermentation method for producing adenosine, which utilizes optimal medium components, optimal pH and dissolved oxygen control ranges for the production of adenosine. High yield of adenosine was obtained under the fermentation process conditions. Background technique

[0002] adenosine [2] , is the medicine of human circulatory system disease. Because adenosine has the function of promoting coronary dilation and myocardial metabolism, dilating blood vessels, and increasing coronary blood volume, it can be used for the treatment of coronary vascular disorders, angina, arteriosclerosis and hypertension. In addition, adenosine and its derivatives can be used as drugs to inhibit blood coagulation, and the effect ...

Claims

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