Preparation method of saffron extract drop pills

A technology of saffron extract and dripping pills, which is applied in the direction of medical preparations containing active ingredients, pill delivery, drug combination, etc., can solve the problems that dripping pills cannot be prepared, and achieve minimal adhesion, uniform size, and dissolution short duration effect

Inactive Publication Date: 2005-11-23
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The preparation method of dripping pills has been disclosed in numerous patent documents, but, because the different active ingredients and different medicines have different medication requirements, the reported method can not be used for the dripping pills with saffron extract as active ingredient. Preparation of pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Melt 15 grams of saffron extract, 15 grams of water, 80 grams of polyethylene glycol 4000 and 40 grams of polyethylene glycol 6000, and then drop them into the coolant through the dripper of the dripping pill machine to absorb the surface of the dripping pill. The cooling agent is dried to obtain the saffron extract dripping pill of the present invention.

[0030] The inner diameter of the dripper of the dripper is 3mm;

[0031] The dripping temperature is 80℃;

[0032] The dripping speed is 19d / min;

[0033] The coolant is liquid paraffin, and the coolant temperature is 0°C;

[0034] The distance between the drip tube of the dripper and the liquid surface of the coolant is 3 cm.

[0035] The test was carried out using the above-mentioned weight difference limit test method, and the results are as follows:

[0036] The weight difference limit was determined under the Appendix IK drop pill catalog of the Pharmacopoeia of the People's Republic of China (2005 edition). The ave...

Embodiment 2

[0038] The same method as in Example 1 is adopted, wherein: the dripping temperature is 70° C., the coolant is methyl silicone oil, and the dripping speed is 30 d / min. The detection result is the same as that of Example 1. The coolant temperature is 0°C.

Embodiment 3

[0040] The dissolution test of the product of Example 1 was carried out using the method specified in the Appendix XIIA Disintegration Time Limit Inspection Law of the Pharmacopoeia of the People's Republic of China (2005 Edition), and the results are as follows:

[0041] The total dissolution time limit is less than 15 minutes. The dripping pill has good roundness, smooth surface, no tailing, little adhesion, moderate dissolution time limit, small weight difference, uniform size, moderate color, good coating, and moderate coating amount.

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PUM

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Abstract

The invention discloses a preparation method of saffron extract drop pills which comprises the following steps, melting safflower extract, water and base material polyethylene glycol (PEG), dropping into cooling material, removing cooling material on the surface of the drop pills, finally drying to obtain the end product.

Description

Technical field [0001] The invention relates to the preparation of a saffron extract preparation, in particular to a preparation method of a dripping pill using the saffron extract as an active ingredient. Background technique [0002] Crocus sativus L is the dried stigma of Crocus sativus L. It is also known as saffron or saffron. It is a traditional Chinese medicine. Its active ingredient is the total glycosides of crocus sativus, which contains crocus glycoside-I. And crocin-II, the active ingredient can be extracted by the method disclosed in the literature of ZL99114025.7 "Pharmaceutical Process and Tablets of Crocus Polyglycoside". Or use commercially available products. Saffron extract is a medicine for the treatment of cardiovascular diseases. It can be used clinically to promote blood circulation, remove blood stasis, cool blood, detoxify, relieve depression and soothe nerves. It is used for amenorrhea scars, postpartum stasis, warm toxin spotting, depression, depression...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 于筛成朱志华赫崇衡刘苗程文辉毛向荣
Owner EAST CHINA UNIV OF SCI & TECH
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