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Oral emulsion combination of 'Chuanhuning'

A composition and technology of Chuanhuning, applied in the directions of antiviral agent, emulsion delivery, etc., can solve the problems of high cost, limited oral bioavailability of Chuanhuning, complicated preparation method, etc., and achieve the effect of improving bioavailability

Inactive Publication Date: 2006-02-01
刘艳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zheng Yong et al. (West China Pharmaceutical Journal, 2003, 18 (2): 101) reported that making enteric-coated capsules of Chuanhuning can improve the oral bioavailability of Chuanhuning, but the preparation method of the preparation is complicated and the cost is high. Oral bioavailability also remains limited

Method used

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  • Oral emulsion combination of 'Chuanhuning'
  • Oral emulsion combination of 'Chuanhuning'

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of soft capsules

[0043] Mix and dissolve the ingredients such as andrographis paniculata 30mg, Tween80 44mg, polyoxyethylene castor oil 120mg, ethyl linoleate 164mg, propylene glycol 36.5mg, vitamin E 9mg and dissolve them completely, add appropriate amount of benzalkonium chloride, and mix well. The mixture is then filled in soft capsules to obtain a soft capsule.

Embodiment 2

[0044] Example 2: Preparation of oral liquid

[0045] Mix and dissolve the ingredients such as andrographolate 90mg, Tween80 219mg, polyoxyethylene castor oil 300mg, isopropyl myristate 519mg, ethanol 60mg, vitamin E 27mg and dissolve them completely, add appropriate amount of benzalkonium chloride and water, and mix Evenly, obtain 3ml of clear mixed liquid, then fill it in a vial, cap, seal, and sterilize by irradiation.

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PUM

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Abstract

An orally-taken composite emulsion of Chuanhuning is prepared from Chuanhuning, surfactant as emulsifier, organic solvent as coemulsifier and oil. It has higher biologic utilization rate.

Description

Invention field [0001] The invention relates to an oral andrographolate emulsion composition with high bioavailability. Background technique [0002] Andrographis paniculata is a dehydroandrographolide succinate half monopotassium salt prepared from the active ingredient andrographolide extracted from the leaves of Andrographis paniculata and succinic anhydride. It is a good antiviral drug with antibacterial, antipyretic and anti-inflammatory effects. It has inactivation effect on influenza virus, respiratory virus, adenovirus, etc., and has obvious inhibitory effect on Staphylococcus aureus, Streptococcus, Escherichia coli, etc. It is often used clinically to treat exogenous fever, acute infectious diseases, urinary tract infections, etc. The curative effect is good, no skin test is needed, and the side effects are few, especially those who are allergic to antibiotics should be the first choice, so it is widely used in clinical practice. However, currently there is only an injec...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/107A61P31/12
Inventor 刘艳李馨儒
Owner 刘艳
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