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Freeze dried oldenlandia powder for injection and its preparation method

A technology for Hedyotis diffusa and freeze-dried powder injection, which are applied in the fields of pharmaceutical preparations and their preparation, freeze-dried powder for injection and their preparation fields, can solve the problems of complex preparation process and preparation technology, and achieve the solution of transportation and storage problems and curative effect. Precise, pain-relieving effect

Inactive Publication Date: 2010-11-17
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, not all original drugs are suitable for powder injection, and the preparation process and preparation technology are relatively complicated, so there is no freeze-dried powder injection of Hedyotis diffusa extract available on the market today.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 Preparation of drug freeze-dried powder injection of the present invention

[0046] 1. Main ingredients

[0047] Hedyotis diffusa extract 28mg (containing 2mg total flavonoids)

[0048] It can be prepared by the following method

[0049] Take 1000g of washed and dried Hedyotis diffusa, grind it into 30 mesh coarse powder, use 2000ml of 80% ethanol as solvent, heat and reflux for extraction 4 times, each time for 1.5h. Combine the extracts, refrigerate for 10 hours, centrifuge, collect the supernatant, add it to the polyamide resin column, adjust the flow rate to 3ml / min, wash away impurities with distilled water, desorb with 80% ethanol as the mobile phase, reclaim the ethanol, and use Adjust the pH value to 3 with 50% sulfuric acid solution, let it stand for 10 hours, filter, adjust the pH value of the filtrate to neutral with 40% NaOH solution, add 2000ml of 80% ethanol, refrigerate for 10 hours, filter, and concentrate the filtrate under reduced pressu...

Embodiment 2

[0064] Embodiment 2 The preparation of drug freeze-dried powder injection of the present invention

[0065] 1. Main ingredients

[0066] Hedyotis diffusa extract 56mg (containing 4mg total flavonoids)

[0067] It can be prepared by the following method

[0068] Take 1000g of washed and dried Hedyotis diffusa, grind it into 30 mesh coarse powder, use 2000ml of 80% ethanol as solvent, heat and reflux for extraction 4 times, each time for 1.5h. Combine the extracts, refrigerate for 10 hours, centrifuge, collect the supernatant, add it to the polyamide resin column, adjust the flow rate to 3ml / min, wash away impurities with distilled water, desorb with 80% ethanol as the mobile phase, reclaim the ethanol, and use Adjust the pH value to 3 with 50% sulfuric acid solution, let it stand for 10 hours, filter, adjust the pH value of the filtrate to neutral with 40% NaOH solution, add 2000ml of 80% ethanol, refrigerate for 10 hours, filter, and concentrate the filtrate under reduced pr...

Embodiment 3

[0082] Embodiment 3 The preparation of drug freeze-dried powder injection of the present invention

[0083] 1. Main ingredients

[0084] Hedyotis diffusa extract 20mg (containing 1mg total flavonoids)

[0085] Its preparation can adopt following method:

[0086]Take 1000g of washed and dried Hedyotis diffusa, grind it into 40 mesh coarse powder, use 2000ml of 70% ethanol as solvent, heat and reflux for extraction three times, each time for 1h. Combine the extracts, refrigerate for 8 hours, centrifuge, collect the supernatant, add it to the polyamide resin column, adjust the flow rate to 4ml / min, wash away impurities with distilled water, use 70% ethanol as the mobile phase for desorption, reclaim the ethanol, and use Adjust the pH value to 4 with 40% sulfuric acid solution, let it stand for 8 hours, filter, adjust the pH value of the filtrate to neutral with 30% NaOH solution, add 1000ml of 70% ethanol, refrigerate for 8 hours, filter, and concentrate the filtrate under redu...

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PUM

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Abstract

The freeze dried oldenlandia powder for injection consists of oldenlandia extract as main material 20-140 weight portions, supplementary material including mannitol 80-200 weight portions, Tween-80 20-100 weight portions and sodium bisulfite 1-6 weight portions, and proper amount of water for injection. The preparation process includes mixing the materials in the weight proportion via stirring todissolve, adding active carbon for injection in 0.1-1 wt%, regulating pH to 6.0-7.0, filtering with 0.4 and 0.22 micron microporous filtering membrane, packing, and freeze drying at 5-10 Pa inside the freeze drying case. The freeze dried oldenlandia powder for injection is used in treating various kinds of inflammation, post-operational infection, etc. as well as the assisting treatment of cancer.

Description

technical field [0001] The invention relates to a pharmaceutical preparation made from extracts of plant materials and a preparation method thereof, more specifically to a freeze-dried powder injection made from Hedyotis diffusa extract and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Chinese herbal medicine Hedyotis diffusa is an annual herb of Rubiaceae, the whole plant of Hedyotis diffusa--Oldenlan-diadiffusa. (Willd.) Roxd. Also known as Hedyotis, it is widely distributed in the south of the Yangtze River in my country. It grows in fields, gardens and wilderness. It is rich in organic germanium, flavonoids, polyphenols, immune polysaccharides, ursolic acid and other compounds. Properties of medicinal materials: The whole grass is twisted into a mass, gray-green or gray-brown, with thin, cylindrical and branched stems. Leaves opposite, nearly sessile, often shrunken, broken or falling off, the whole ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/76A61K9/19A61P35/00A61P1/16A61P11/00A61P13/00A61P15/00
Inventor 丁钉生
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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