Method and devices of biochemical detection by using micro semi girder

A technology of micro-cantilever beam and biochemical detection, which is applied in measuring devices, material analysis by electromagnetic means, scanning probe microscopy, etc., can solve the problems of biosensor sensitivity limitation and sensitivity limitation, and achieve high sensitivity and easy operation Effect

Inactive Publication Date: 2006-07-05
INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Most of the existing biochemical sensors are designed as diaphragm type, and the sensitivity of biosensors is also limited due to the sensitivity limitation of signal conversion devices.

Method used

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  • Method and devices of biochemical detection by using micro semi girder
  • Method and devices of biochemical detection by using micro semi girder
  • Method and devices of biochemical detection by using micro semi girder

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0025] Such as figure 1 As shown, the micro-cantilever beam 4 is rectangular and fixed on the supporting chip 12 .

[0026] Such as figure 2 As shown, the present invention includes a laser tube 1, a first reflector 2, a lens 3, a micro-cantilever beam 4, a draft tube 5, a second reflector 7, a position sensitive detector 8, a sample pool 6, and a constant temperature control device 9 . The first reflector 2 is fixed in front of the laser tube 1, and the mirror surface of the first reflector 2 forms a certain angle with the laser incident ray, so as to ensure that the laser light can be reflected to the lens 3 through the first reflector 7, and the lens 3 is a cylinder. The lower plane of the cylinder cuts out an inclined plane at a certain angle with the lower plane from the midline position, and the rear half part of the microcantilever b...

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Abstract

The invention is a biochemical detecting method and device using micro cantilever beam, using a micro cantilever made of silicon coated with biochemical sensitive layer as a biochemical molecule detecting element. As the measured matter enters into the bio-sensitive layer, the bio-sensitive layer absorbs the molecules of the measured matter to make the molecules of the measured matter and those of the bio-sensitive layer interact on each other by force so as to make the micro cantilever beam generate a surface stress whose change will bend the micro cantilever beam, a laser beam reflected from the back of the micro cantilever beam is received by a position sensitive detector, the deformation of the micro cantilever beam will make the laser spot shift on the position sensitive detector, the position sensitive detector converts the optical signal displacement into an electric signal, which is collected through a data collection card into a computer and expressed by image. The invention has high sensitivity and can serve as a biochemical sensor for detecting trace biochemical molecules.

Description

technical field [0001] The invention relates to a biochemical detection method and device using a micro-cantilever beam. Background technique [0002] The basic principle of biosensors for detecting various biological and chemical substance molecules is the physical or chemical adsorption of the analyzed molecules on the biochemical sensitive layer, which is converted into electrical signals by transducers. Most of the existing biochemical sensors are designed as diaphragm type, and the sensitivity of the biosensor is also limited due to the sensitivity limitation of the signal conversion device. [0003] Scanning Probe Microscope SPM (Scanning Probe Microscope) is a new type of surface analysis instrument based on physics and integrating a variety of modern technologies. It is a major tool for nanotechnology research and is the highest resolution microscope in the world. Atomic force microscopy (AFM) is one of many members of the scanning probe microscope SPM family, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/28G01N13/10G01Q60/28
Inventor 左燕生林云生赵惠斌韩立
Owner INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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