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Compound spraying agent for rhinitis, and preparation method

A spray and rhinitis technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of small contact area of ​​nasal mucosa, lower drug efficacy, penetration of propellants, etc., and achieve the effects of reducing gastrointestinal side effects, convenient use, and prolonged residence time

Inactive Publication Date: 2006-12-06
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ointment is squeezed into the nasal cavity in strips, and the contact area with the nasal mucosa is small, so it is often difficult to absorb or incompletely absorbed
Made into oral preparations, due to the influence of the first-pass effect of the liver, the efficacy of the drug will be reduced
Although aerosols have similar advantages to sprays, they require pressure-resistant containers and valve systems, and sometimes fail due to the penetration of propellants due to poor packaging

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh the following ingredients:

[0019] 150g of Andrographis paniculata concentrate, 25g of Goose Bubivora concentrate, 5g of ephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 45g of Span 80.

[0020] Mix ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, andrographis paniculata concentrate and goose non-grass concentrate, add appropriate amount of water to dissolve, filter, stir well, add peppermint oil and eucalyptus oil and mix well (add 10g ethanol to dissolve) , then add Span 80, add water to 1000g, stir evenly, and you get it.

Embodiment 2

[0022] Weigh the following ingredients:

[0023] 150g of Andrographis paniculata concentrate, 25g of Goose Bubivora concentrate, 5g of ephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 20g of Tween 80.

[0024] Mix ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, andrographis paniculata concentrate and goose non-grass concentrate, add appropriate amount of water to dissolve, filter, stir well, add peppermint oil and eucalyptus oil and mix well (add 50g ethanol to dissolve) , then add Tween 80, add water to 1000g, stir evenly, that is.

Embodiment 3

[0026] Weigh the following ingredients:

[0027] 150g of Andrographis paniculata concentrate, 25g of Goose Bubivora concentrate, 5g of ephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 30g of Span 80.

[0028] Mix ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, andrographis paniculata concentrate and goose non-grass concentrate, add appropriate amount of water to dissolve, filter, stir well, add peppermint oil and eucalyptus oil and mix well (add 100g ethanol to dissolve) , then add Span 80, add water to 1000g, stir evenly, and you get it.

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PUM

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Abstract

A medicine in the form of aerosol for treating rhinitis is prepared from ephedrine hydrochloride, benadryl hydrochloride, and the concentrated liquid extracts of green chiretta and small centripeda herb through dissolving in water, filtering, stirring, adding mint oil and eucalyptus oil, stirring, adding tween-80 (or span-80), adding water and stirring.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine prescription preparations, and specifically relates to a compound rhinitis spray and a preparation method thereof. Background technique [0002] Traditional Chinese medicine preparations for the treatment of rhinitis generally adopt the route of oral administration, and some are made into nasal drops, aerosols, sprays, ointments, etc. The ointment is squeezed into the nasal cavity in strips, and the contact area with the nasal mucosa is small, so it is often difficult or incomplete to absorb. Made into oral preparations, due to the influence of the liver's first-pass effect, the curative effect of the drug will be reduced. Although aerosols have similar advantages to sprays, they require pressure-resistant containers and valve systems, and sometimes fail due to the penetration of propellants due to poor packaging. Contents of the invention [0003] The object of the present inventio...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/12A61P11/02A61K31/137A61K31/138
Inventor 董大伦
Owner GUIYANG XINTIAN PHARMA CO LTD
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