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A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same

A kind of niclosamide, nano suspension technology

Inactive Publication Date: 2006-12-27
JIANGSU INST OF PARASITIC DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the unsatisfactory solubility and dispersibility of various powders of niclosamide, small lumps of precipitates are easy to block the spraying equipment, resulting in difficulty in use and uneven concentration of the liquid solution, resulting in a decline in the molluscicide effect

Method used

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  • A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same
  • A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same
  • A snail-killing medicine-nano suspension concentrate of niclosamide ethanolamine and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of niclosamide nano-suspension

[0029] Formula: 25% of niclosamide, 0.1% of polyoxyethylene, 10% of Tween-80, 5% of methyl silicone oil, the rest is water, and the total amount of the sample is 20g.

[0030] Use zirconia balls, the ratio of balls to materials is 20:1, and the speed is 1000r / min. First, mix large balls with a diameter of 8mm and small balls with a diameter of 4mm. The weight ratio of large and small balls is 1:2. Grinding with 1mm diameter balls for 20-100 hours.

Embodiment 2

[0031] Embodiment 2: the preparation of niclosamide nano-suspension

[0032] Formula: 15% of niclosamide, 0.05% of polyvinyl alcohol, 15% of sodium dodecylbenzenesulfonate, 10% of methyl silicone oil, and the rest is water, and the total amount of the sample is 20 g.

[0033] Zirconia balls are used, the ball-to-material ratio is 10:1, and the rotation speed is 200r / min. Firstly, grind with a 4mm diameter ball for 5-40 hours, and then use a 1mm diameter ball for 20-100 hours.

Embodiment 3

[0034] Embodiment 3: the preparation of niclosamide nano-suspension

[0035] Formula: 20% of niclosamide, 0.5% of polyacrylamide, 3% of Tween-80, 1% of silicone X-10, the rest is water, and the total amount of the sample is 20g.

[0036] Zirconia balls are used, the ball-to-material ratio is 15:1, and the rotation speed is 600r / min. Firstly, use 8mm diameter balls to grind for 5-40 hours, and then use 1mm diameter balls to grind for 20-100 hours.

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Abstract

The invention provides a niclosamide nano suspending agent as a medicament for controlling oncomelania hupensis and its preparing process, wherein the basic constituents include (by weight percent) niclosamide 15-25%, water-soluble high polymer 0.05-0.5%, surface active agent 3-15%, defoaming agent 1-10%, and balancing water as dispersion medium.

Description

technical field [0001] The invention discloses a nano-suspension agent of niclosamide which kills molluscs and a preparation method thereof, and belongs to the technical field of nano-preparations of molluscicides and insoluble drugs. Background technique [0002] With the development of nanotechnology, the nanotechnology of poorly soluble drugs is an important way to research and develop high-efficiency preparations. The nano-preparation of insoluble drugs has a large surface area and a high degree of dispersion, which can improve the solubility of the drug, make the drug more easily absorbed by the organism, and better exert the drug effect; secondly, due to its small particle size, the nano-particles are easier to penetrate Through the epidermis and biofilm in the body, it is convenient to enter the focus of the organism and improve the bioavailability of the drug; at the same time, the combination of nanoparticles and carriers can also better solve the problem of slow re...

Claims

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Application Information

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IPC IPC(8): A01N37/48A01N25/04A01N25/30A01P9/00
Inventor 朱荫昌李新松戴建荣郭峰梁幼生
Owner JIANGSU INST OF PARASITIC DISEASES
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